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Acetyl-Histone H2B type 1-B (K20) Recombinant Monoclonal Antibody

Acetyl-Histone H2B type 1-B (K20) Recombinant Monoclonal Antibody

CSB-RA010402A20acHU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA, WB, ICC, IF, FC

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Target Background

Product Details

Uniprot NO.

P33778

Alternative Names

HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody

Species Reactivity

Human

Immunogen

A synthesized peptide

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

21F11

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Scope Application

ELISA, WB, ICC, IF, FC

Recommended Dilution

Application	Recommended Dilution
WB	1:5000-1:10000
ICC	1:50-1:500
IF	1:30-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol Flow Cytometry (FC) Protocol

Datasheet & COA

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Acetyl-Histone H2B type 1-B (K20) Recombinant Monoclonal Antibody

Description

The acetyl-Histone H2B type 1-B/HIST1H2BB (K20) recombinant monoclonal antibody is a highly specific antibody against the acetylated HIST1H2BB at K20 from human and mouse sources. This acetyl-HIST1H2BB (K20) antibody was expressed by transfecting the human acetyl-HIST1H2BB (K20)monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. Its isotype matches with the rabbit IgG. This acetyl-HIST1H2BB (K20) antibody can be used in ELISA, WB, ICC, IF, and FC applications.

HIST1H2BB is a subtype of histone core component H2B. Antibodies against the HIST1H2BB are useful for the localization and detection of the HIST1H2BB of acetylation at Lys20 residue.

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Target Background

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene References into Functions

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID:29643390
RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID:26854224
RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID:21362548

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Subcellular Location

Nucleus. Chromosome.

Protein Families

Histone H2B family

Database Links

HGNC: 4751

UNIGENE: Hs.553494

KEGG: hsa:3018

STRING: 9606.ENSP00000350580

OMIM: 602803

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