ANGPT1 Recombinant Monoclonal Antibody

1. ERG is an endothelial transcriptional effector activated downstream of Ang1 to promote Notch signalling and vascular stability. Ang1 is able to phosphorylate ERG via PI3K/Akt, and this promotes the formation of an ERG-beta catenin complex, which binds multiple sites in the Dll4 locus and drives Dll4 expression. PMID:28695891
2. miR-876-5p suppressed proliferation by restraining the expression of Ang-1, which would regulate the phosphorylation level of PI3K, AKT, mTOR and ERK in psoriasic cells. PMID:29864894
3. hyperoxia as well as increased TGFbeta signaling is a major contributor to the increased levels of miR34a, which mediate injury via angiopoietin-1 in neonatal lungs PMID:29079808
4. High Angpt2 and low Angpt1 levels were positively associated with abnormal cardiac structure. PMID:27991547
5. findings reveal a novel role for miR-204/ANGPT1/TGFbetaR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer. PMID:27703260
6. VEGF plays a role in the induction of of ANGPT1 in skeletal muscle to stimulate angiogenesis. PMID:29517203
7. no significant difference in liver expression between chronic hepatitis C patients and controls PMID:28027429
8. serum Ang-2 and Ang-1 levels may help in the diagnosis of patients with lymphatic anomalies and are concordant to sirolimus response. PMID:27990590
9. Studied role of change in ratio of angiopoietin-2 (Ang-2) to angiopoietin-1 (Ang-1) levels in hantavirus ionfections. Found imbalance in ang-2:ang-1 lasted through the acute infection phase. PMID:28734140
10. Bicarbonate buffered PD fluid promotes vessel maturation via upregulation of angiopoietin-1 in vitro and in children on dialysis PMID:29253861
11. When Tie2 becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2, Angiopoietin-1 and Angiopoietin-2, regulate its activation status. PMID:28582314
12. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2. PMID:28766001
13. study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed. PMID:28956132
14. These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma. PMID:28920924
15. Ang-1 specifically increases circulating Gr1(+ )inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis. PMID:28069704
16. NOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells. PMID:28351775
17. ANG-1, ANG-2 and TIE-2 levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception. PMID:28238760
18. study is the first one to report Ang1 capacity to induce MIP-1beta gene expression, protein synthesis and release from neutrophils, and that these effects are mediated by PI3K, p38 MAPK and MEK activation and downstream NF-kappaB activation PMID:27632174
19. In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer. PMID:28720059
20. Data show that fibulin-5 strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 receptor axis. PMID:27304216
21. Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension PMID:27802345
22. We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 and -2 and their binding receptor Tie2 may play a role in the angiogenesis associated with the development of these lesions. PMID:26695562
23. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand Ang-1, but not the receptor binding domain of Ang-2, can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK signaling in the presence of both Ang-1 and fibronectin PMID:27695111
24. Results uncovered ZO-1 as part of a signaling node activated by VEGF, but not Ang-1, that specifically modulates endothelial cells proliferation during angiogenesis. PMID:26846344
25. there was no immunohistochemical evidence for apoptosis or autophagy. Quantitative staining showed similar expression levels of the angiogenesis regulators VEGF-A, VEGF-receptor 2 and Angpt1 (p = 0.11), but Angpt2 was significantly lower in CKD children (p = 0.01). PMID:27846250
26. Ang-1 and -2 levels and the Ang-2/Ang-1 ratio may be promising indicators of disease activity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli. PMID:26945868
27. l-thyroxine increased Ang1 expression and induces bone formation, differentiation, and mineralization in U2OS and MG63 cell lines. PMID:27569283
28. Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1/ Tie-2 signaling pathway. PMID:27894114
29. We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities. PMID:27137842
30. Plasma Ang-1 levels were diminished in Behcet's disease patients, especially in patients with vascular involvement. PMID:25964071
31. Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target. PMID:27956798
32. Data suggest that ANGPT1 is active in tight junctions and adherens junctions in the up-regulation of pathophysiological angiogenesis in ovarian follicles in ovarian hyperstimulation syndrome. Follicular fluid from women at risk of ovarian hyperstimulation syndrome in Argentina was used in these studies. PMID:25485810
33. the results of the present study suggest that aHSCs increased the expression of Ang-1, resulting in angiogenesis in HCC tissues, thus promoting the growth and metastasis of HCC. PMID:27358066
34. Results found that MCT contributes to endothelial cell growth and tube formation via up-regulation of angiopoietin-1 expression suggesting that MCT plays an important role in pancreatic cancer angiogenesis and tumor growth via activating the angiopoietin-1 pathway. PMID:27240355
35. Angiopoietin 1 levels were significantly higher in nasopharyngeal cancer patients. PMID:26758427
36. High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion. PMID:27111031
37. GTPCH/Ang-1 interaction in stromal fibroblasts and activation of Tie2 on breast tumor cells could play an important role in supporting breast cancer growth. PMID:26814432
38. the homeostasis of vascular endothelial function by Ang-1 and Ang-2 is disrupted in macrophage activation syndrome (MAS); the Ang-2/1 ratio was significantly elevated in the active phase of s-JIA; serum Ang-1 levels were significantly decreased in MAS, whereas the serum Ang-2 levels and the Ang-2/1 ratio were significantly elevated in MAS PMID:26908294
39. ANGPT1 may be associated with taxol resistance of nasopharyngeal carcinoma cells. PMID:26722421
40. ANGPT1, ANGPT2, and VEGF are associated with development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. PMID:26489624
41. AGP1 is downregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease. PMID:26908325
42. In this study found that serum Ang-1 levels were significantly higher at 72 hours post-hemorrhage among aSAH patients. PMID:26208799
43. For the diagnosis of HELLP syndrome, increased levels of ET-1,M30 and Angs-1 [Angiopoietin-1] and -2 [Angiopoietin-2]appear as promising biomarkers after determination of their standardized threshold levels PMID:26138305
44. H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. PMID:25413303
45. Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin PMID:26090670
46. Genetic variations of ANGPT1 were associated with increased infarct size and disease susceptibility. PMID:26542693
47. The distribution of the other genotypes (rs2507800, rs1954727 and rs1010824 of ANGPT1 was not significantly different between patients with psoriasis vulgaris and the healthy controls. PMID:25753570
48. Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness. PMID:26090803
49. Ang-1 disrupts TLR4 signalling, resulting in inhibition of LPS-induced inflammatory responses in endothelial cells. This inhibition occurs through selective targeting of IRAK1 and TRAF6 proteins by miR-146b-5p. PMID:25824148
50. Gingipains from the Porphyromonas gingivalis play roles in regulation of angiopoietin 1 and angiopoietin 2 in human aortic smooth muscle cells. PMID:26283334

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HGNC: 484

UNIGENE: Hs.369675

KEGG: hsa:284

STRING: 9606.ENSP00000428340

OMIM: 601667