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Recombinant Human papillomavirus 11 Protein E6 (E6)

Recombinant Human papillomavirus 11 Protein E6 (E6)

Code: CSB-EP361193HMGa2

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Size:

20ug100ug1mg

US$388

Quantity:

Express system: E.coli

Species: Human papillomavirus 11

Tag Info: N-terminal 6xHis-SUMO-tagged

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Product Details
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Target Background

Product Details

Abbreviation

Recombinant Human papillomavirus 11 E6 protein

Purity

≥ 85% as determined by SDS-PAGE.

Target Names

Uniprot NO.

P04019

Research Area

Cancer

Species

Human papillomavirus 11

Source

E.coli

Expression Region

1-150aa

Mol. Weight

35.6 kDa

Protein Length

Full Length

Tag Info

N-terminal 6xHis-SUMO-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Datasheet & COA

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Target Background

Function(From Uniprot)

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation. In turn, apoptosis induced by DNA damage is inhibited. E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.

Subcellular Location

Host cytoplasm. Host nucleus.

Protein Families

Papillomaviridae E6 protein family

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