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Recombinant Xenopus tropicalis Serine/threonine-protein kinase PLK4 (plk4), partial

Recombinant Xenopus tropicalis Serine/threonine-protein kinase PLK4 (plk4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

plk4

Uniprot NO.

B3DL84

Alternative Names

plk4; sak; Serine/threonine-protein kinase PLK4; EC 2.7.11.21; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase Sak

Species

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Source

Yeast

Expression Region

1-946

Target Protein Sequence

MAGSIGERRE DFKVLNLLGK GSFACVYRAQ SINTGIDVAI KMIDKKAMQK VGMVQRVRNE VEIHCQLKHP SILELYNYFE DSNYVYLILE MCHNGEMNRF LKNRKKPFSE DEARHFMHQI VTGMLYLHSH GILHRDLTLS NLLLSSDMNI KIADFGLATQ LKMPNEKHFT MCGTPNYIAP EIATRSAHGL ESDVWSLGCM LYTFLVGRPP FDTDTVKNTL NKIVLADYEM PDFVSREAKD LIFQLLRKNP ADRLSLSSVL DHAFMTGFSN VQSKVMGAVE DSIDSGHATI STGFTGSSGV SISGRFQEKR ILSGPSLPNK VNIFQFKDKH PAERSNGGSF HNTQRENNDF SEGNGRKTVA CEDRPHSRYL RRAHSSDRSG TSQSQTYGKP SSFSERCHSV EMLAKPSNLK GYCTSSPPKS YGDIPQMFTD ERSLERHTSP PVKEKTPSEF MCPAKQITPR SGDKCQAETV QQWFGAMQLN GKFKNTPDTS SVSNMGGDFY SQQTMQNGAP QYAWNDVKRK KDTDSSVESV LRGISKLPSG QHKAEKSQFG EQSKARVPQQ AFGSSTLRSI ISPLNAERLK PIRQKTKNAV VSILETGEVC MEFLKEQNSQ ERVKEVLRIS CDGNLIYVYH PNEGKGFPLV ERPPSPPENM RSYTFDSLPE KYWKKYQYAA KFIQLVRSKM PKVTYYTRYA KCMLMENGPN ADFEVCFYDG AKIHKTPDLI RVIEKSGKSY TVEGSRLSTL SDQVRSYVNH ANESHCVCLS LESAINTEEK KGENISLFPI TFGRRPAITE SPRTQLTVDS ARERKDEQSS ANRVLHSSAT SPPQIPNINP SLISYEGSVF SATTAQPSPP TSNTLKTHAP DRAQVLKSVF VENVGWASQL NSGAVWVQFN DGSQLVVQPG VSSIIYTAPN GQITRHGEND KLPEYIKSKL QCLSSILMLF ASSSSH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles.

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily

Database Links

UNIGENE: Str.52651

KEGG: xtr:100038180

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