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Recombinant Xenopus tropicalis Homeobox protein OTX2 (otx2)

Recombinant Xenopus tropicalis Homeobox protein OTX2 (otx2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

otx2

Purity

>85% (SDS-PAGE)

Target Names

otx2

Uniprot NO.

Q28FN6

Alternative Names

otx2; TGas114a06.1; Homeobox protein OTX2; Orthodenticle 2

Species

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Source

Yeast

Expression Region

1-289

Target Protein Sequence

MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP SKKKPSPARE VSSESGTSGQ FSPPCSTSVP VISSSTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLSGAGATLS PMGTNAVTSH LNQSPAALSS QAYGASSLGF NSTADCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression.

Gene References into Functions

Otx2 upregulate or downregulate a large battery of target genes in the head organizer. PMID:25005894
The obligate integration of inputs of a field-selector (Otx2) and localized signaling (Notch) within target cis-regulatory elements might be a general mechanism of organ-field specification in vertebrates (as it is in Drosophila). PMID:18057103

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Subcellular Location

Nucleus.

Protein Families

Paired homeobox family, Bicoid subfamily

Database Links

UNIGENE: Str.10021

KEGG: xtr:548931

STRING: 8364.ENSXETP00000034219

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