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Recombinant Xenopus tropicalis Fragile X mental retardation protein 1 homolog (fmr1), partial

Recombinant Xenopus tropicalis Fragile X mental retardation protein 1 homolog (fmr1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

fmr1

Purity

>85% (SDS-PAGE)

Target Names

fmr1

Uniprot NO.

Q6GLC9

Alternative Names

fmr1Synaptic functional regulator FMR1; Fragile X mental retardation protein 1 homolog; FMRP; Protein FMR-1; XtFmrp

Species

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Source

Yeast

Expression Region

1-590

Target Protein Sequence

MEELAVEVRG SNGAFYKAFV KDVHEDSITV TFENNWQQER QIPFHDVRFP PPSGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP ATKNSFHKVK LDVPEDLRQM CAKDSAHKDF KKAVGAFSVS YDSENYQLVI LSVNEVTIKR ANMLSDMHFR SLRTKLSLML RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV TAIDLDEDTC TFHIYGEDQE AVKKARTYLE FAEDVIQVPR NLVGKVIGKN GKLIQEIVDK SGVVRVRIEA ENDKNISPEE GMVPFVFVGT KDSITNATVL LDYHLNYLKE VDQLRLERLQ IDEQLRQIGA SSRPPPNRPD KEKGYQSEDL SGTGRGSRPY NNRGRSRRGT GYASDIRYGD PDYRKTTYPE YPRSQAFWIK GTNSEASNAS ETESDHRDEL SDWSLAPAED DRDNYHRRGD GRRRGGPRGQ GMRGRGGFKG NDDQPRPDNR QRNSRETKAR TSDGSLQIRI DCNNERSVHT KTLQNASVEG SRLRTGKDRV QKKEKSEVVD GPQVVVNGIP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C).

Gene References into Functions

Fmr1 is expressed ubiquitously throughout the embryo during embryonic development. PMID:15968590

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Subcellular Location

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Chromosome. Cytoplasm, perinuclear region. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, synaptosome. Cell projection, growth cone. Cell projection, filopodium tip. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Cell membrane. Cytoplasm, Stress granule.

Protein Families

FMR1 family

Tissue Specificity

Expressed ubiquitously throughout the embryo. Shows tissue-specific expression in adults, being abundant in most neurons of the central nervous system (CNS) and in all spermatogenic cells of the testis.

Database Links

UNIGENE: Str.20888

KEGG: xtr:448049

STRING: 8364.ENSXETP00000042153

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