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Recombinant Xenopus tropicalis Dual specificity tyrosine-phosphorylation-regulated kinase 1A (dyrk1a), partial

Recombinant Xenopus tropicalis Dual specificity tyrosine-phosphorylation-regulated kinase 1A (dyrk1a), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

dyrk1a

Purity

>85% (SDS-PAGE)

Target Names

dyrk1a

Uniprot NO.

Q0IJ08

Alternative Names

dyrk1a; mnbDual specificity tyrosine-phosphorylation-regulated kinase 1A; EC 2.7.12.1; Protein kinase minibrain homolog

Species

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Source

Yeast

Expression Region

1-751

Target Protein Sequence

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRRQQNLN DQQASALPYN DQIQQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT KDGKKEYKPP GTRKLHNLLG VETGGPGGRR GGESGHTVAD YLKFKDLILR MLDYDAKTRI QPYYALQHSF FKKTADEGTN TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPPGWTV PEAPTQVTIE THPVQETTFH VPSSQQNVPH HHGNGSHHHH HHHHHHHGQH VLSNRTRTRI YNSPSTSSST QDSMDVGHSH HSMTSLSSST TSSSTSSSST GNQGNQAYQN RPVAANTLDF GQNGTMDVNL TAFSNPRQET GITGHPDYQY SANTGPGHYV TEGHLTMRQG MDREDSPMTG VCVQQSPVAS S
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

Gene References into Functions

Selective inhibition of the kinase DYRK1A by targeting its folding process can rescue DYRK1A-induced developmental malformations in Xenopus laevis embryos. PMID:27102360

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Subcellular Location

Nucleus speckle.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily

Database Links

UNIGENE: Str.49084

KEGG: xtr:779733

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