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Recombinant Xenopus laevis Zinc finger protein ZIC 1 (zic1)

Recombinant Xenopus laevis Zinc finger protein ZIC 1 (zic1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

zic1

Uniprot NO.

O73689

Alternative Names

zic1; oplZinc finger protein ZIC 1; XZic1; XlZic1; ODD-paired-like; Xopl; ZIC-related protein 1; ZIC-r1; Zinc finger protein of the cerebellum 1

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-443

Target Protein Sequence

MLLDAGAQYP AIGVTTFGSS RHHSAGDVTD REVALGINPF ADGMGAFKLN PSSHDLASGQ TAFTSQAPGY AAAALGHHHH PGHVSSYSSA AFNSTRDFLF RNRGFGEAAS AQHSLFASAA GGFPGPHGPH ADTTGHLIFP GLHEQAASHA SPNVVNGQMR LGFSGDMYGR PDQYGQVTSP RSEHYASSQL HGYGPMNMNM AAHHGAGAFF RYMRQPIKQE LICKWIEPEQ LANPKKSCNK TFSTMHELVT HVTVEHVGGP EQSNHICVWE ECPREGKPFK AKYKLINHIR VHTGEKPFPC PFPGCGKVFA RSENLKIHKR THTGEKPFKC EFEGCDRRFA NSSDRKKHMH VHTSDKPYLC KMCDKSYTHP SSLRKHMKVH EASSQGSQPS PAASSGYESS TPPTIVSPSA ENQSTSSLSP SSSAVHHTSN HSTLSSNFNE WYV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border. Cooperates with pax3 in concert with wnt signaling to determine neural crest fate. Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Gene References into Functions

Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. PMID:26101153
Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers. PMID:24360906
Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos. PMID:23509273
Co-activation of Pax3 and Zic1, in concert with Wnt, plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm. PMID:15843410
These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression PMID:16307736
Zic1 directly upregulated the Xfeb gene during early neural development. PMID:16871635
Zic1 is an activator of Wnt signaling. PMID:16892174
Data show that Pax3 and Zic1 are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest. PMID:17409353
aqp-3b was upregulated by Zic1 PMID:19384961

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

GLI C2H2-type zinc-finger protein family

Tissue Specificity

During early gastrula stages, widely expressed in the dorsal ectoderm. At mid-gastrula, expressed throughout the presumptive neural plate and at late gastrula, expression gradually diminishes in the dorsal midline and increases in the anterior folds. By e

Database Links

UNIGENE: Xl.1796

KEGG: xla:399124

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