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Recombinant Xenopus laevis Structural maintenance of chromosomes protein 1A (smc1a), partial

Recombinant Xenopus laevis Structural maintenance of chromosomes protein 1A (smc1a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

smc1a

Uniprot NO.

O93308

Alternative Names

smc1a; smc1; smc1l1; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1A; xSMC1

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-1232

Target Protein Sequence

MGFLKLIEIE NFKSYKGRQI IGPFHRFTAI IGPNGSGKSN LMDAISFVLG EKTSNLRVKT LRDLIHGAPV GKPAANRAFV SMVYSEDSGE EKVFSRVIVG GSSEYKINNK VVQLSEYSDS LEKLGILIKA RNFLVFQGAV ESIAMKNPKE RTALFEEISR SGELAQEYDK RKKEMVKAEE DTQFNYHRKK NIAAERKEAK QEKEEAERYQ RLKDEVARAQ IQLQLFKLYH NESEIEKLNK ELSVKNKGIE KDKKHMDKVE EELKDKKKEL GKMMREQQAI EKEIKEKDAE LNQKLPQYIK AKENPSHKIK KFRAAKKSLQ NAQKQYKKRK ADMDELEKEM LSVEKARQEF EERMEEESQS QGRDLTLEEN QVKKYHRLKE EASKRAATLA QELEKFNRDQ KADQDRLDLE ERKKVETEAK IKQKLRELEE NQKRIEKLEE YIATSKQSLE EQKNLEETLT EEVEMAKRRI DEINSELNQV MEQLGDARID RQESSRQQRK AEIMESIKRL YPGSVYGRLI DLCQPTQKKY QIAVTKVLGK NMDAIIVDSE KTGRDCIQYI KEQRGEPETF LPLDYLEVKP TDERLRELKG AKLVIDVIRY EPPHIKKALQ YACGNALVCD NVEDARRIAF GGHQRHKTVA LDGTLFQKSG VISGGASDLK AKARRWDEKA VDKLKEKKER LTEELKEQMK AKRKEAELRQ VQSQAHGLQM RLKYSQSDLE QTKTRHLAMN MQEKSKLESE LANFSPRIND IKRIIQSRDR EMKDLKEKMN QVEDEVFEEF CREIGVRNIR EFEEEKVKRQ NEIAKKRLEF ENQKTRLGIQ LDYEKNQLKE DQGKVQTWEQ SVKKDDNEIE KLKKEEQRHM KIIDETMAQL QDLKNQHLAK KSEVNDKNHL MEDIRKKLGS ANKEVTHLQK EVTAIETKLE QKRSDRHNLL QACKMSDIKL PLSKGTMDDI SQEEGSSQGE ESASSSQRSS TVYAKEALIE IDYSDLSEDL KDAVADDDIK QEMSALHQKI NEQQSILQRI SAPNMKAMEK LESVRDKFQE TSDEFEAARK RAKKAKQAFE QTKKERFDRF NACFESVATN IDEIYKALSR NSSAQAFLGP ENPEEPYLDG INYNCVAPGK RFRPMDNLSG GEKTVAALAL LFAIHSYKPS PFFVLDEIDA ALDNTNIGKV ANYIKEQSMS NFQAIVISLK EEFYTKAESL IGVYPEQGDC VISKVLTFDL TKYPDANPNP ND
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.

Subcellular Location

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.

Protein Families

SMC family, SMC1 subfamily

Database Links

UNIGENE: Xl.4734

KEGG: xla:100379087

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