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Recombinant Xenopus laevis Stromal cell-derived factor 1 (cxcl12)

Recombinant Xenopus laevis Stromal cell-derived factor 1 (cxcl12)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

cxcl12

Purity

>85% (SDS-PAGE)

Target Names

cxcl12

Uniprot NO.

Q8UUJ9

Alternative Names

cxcl12; sdf1; Stromal cell-derived factor 1; xSDF-1; C-X-C motif chemokine 12

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

22-94

Target Protein Sequence

KPVSLVYRC PCRYFESNVP KSNIKHLKIL STSNCSLQIV ARLKHNGKQI CLDPKTKWIQ EYLEKALNKK AKKT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Chemoattractant. Activates the C-X-C chemokine receptor cxcr4 to induce a rapid and transient rise in the level of intracellular calcium ions, and chemotaxis. Signaling with cxcr4 mediates the directional movement of mesodermal cells during gastrulation (Ref.2). Binds to the allosteric site (site 2) of integrins and activates them in a cxcr4-independent manner.

Gene References into Functions

These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog. PMID:24357195
SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus PMID:19770040
A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls. PMID:15019705
SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation. PMID:17239342

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Subcellular Location

Secreted.

Protein Families

Intercrine alpha (chemokine CxC) family

Tissue Specificity

Isoform alpha is expressed throughout the inner deep cells of the blastocoel roof during gastrula stage embryos. Isoform beta is expressed in the developing central nervous system (CNS) of embryos; at stages 21-23, up-regulated in the anterior of the embr

Database Links

UNIGENE: Xl.4813

KEGG: xla:399030

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