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Recombinant Xenopus laevis Serine/threonine-protein kinase atr (atr), partial

Recombinant Xenopus laevis Serine/threonine-protein kinase atr (atr), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

atr

Purity

>85% (SDS-PAGE)

Target Names

atr

Uniprot NO.

Q9DE14

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-2654

Target Protein Sequence

MATDPGLEMA SMIPALRELA SAGAEEYNTT VQKPRQILCQ FIDRILTDVD VVAVELSKNT DSQPSSVMLL DFIQHIMKST PLMFLSANNG DQSAETNQNC VAFSNWIISR LLRIGATPSC KALHRKIAEV IRSLLFLFKN KSSFLFGVFT KDLLHLFEDL IYIHEQNMEK SVVWPVTISR FLSNASENQT YLRCTQFQLL NMQNIEPLES TLLMVLMDNE HDISPVFFQR QNLLLWGIGC SLLDYGSTPL KIQALHFLRQ LIKLGGPPEQ GAYFFFIVFF GILTCIKDMD LEEVSLYEMP LLKLVKVLFP FESKSYLNIE PVYLNMLLEK LAALFDGGIL SNIQSAPLKE ALCYMVHYFL SIVPPGYESA KEVREAHVRC ICRAFVDVLG LQSKQEYLVC PLHEALRIEN LVFMQQQRMQ PLSTDSEGGG SSSSDEVQEK RPRLSLTAKP LRRNTPSVPA PVDMKTKSIL WKAVSAKFSS ILCKLEGDEV TDEEMVSLLE GLNTTVRVAA LNTVHIFTND STDTDQLVSD LSNTSGIQSV EIVPHVFWLS PEDILKILKI CRKVLDSAHQ RANINDILMK IIKIFDAILY IHAGNRLNDQ TLKDLCSMIS LPWLQNHSNH ASFKVASFDP TLMTISERIG QHYSPEIQSQ LVFLLCLFPK MLCPEWRLAV YQWALDSPHE IVRARCIKGF PVLLCNVSQQ GYGPIPKILI DCLNDASELV KKELANSVGM FASGLACGFE LQYSPTAPTA AESEFLCSSL TVTALPSSKL SRMTASALKP FLALLNRNMP SSVKMAFIEN MPMLFAHLSL EKDDLDSRTV IESLLNLMED PDKDVRTAFS GNIKHLLACA DCEDGYLKEI VVSRMKKAYT DAKMSRDNEM KDTLILTTGD IGRAAKGELV PFALLHLLHC LLSKSPCVAG ASYTEIRSLA AAKSTSLHIF FSQYKKPICQ FLIESLHSSQ AALLTNTPGR SSEMQKQEAT HHREAALDIL SEIANVFDFP DLNRFLTRTL QLLLPYLAAK ASPTASTLIR TIAKQLNVNR REILINNFKY IFSHLVCSCT KDELEKSLHY LKNETEIELG SLLRQDYQGL HNELLLRLGE HYQQVFSGLS ILATYASNDD PYQGPRNFAK PEIMADYLQP KLLGILAFFN MHLLSSSIGI EDKKMALNSL VSLMKLMGPK HISSVRVKMM TTLRTGLRYK EEFPGLCCSA WDLFVRCLDQ AYLGPLLSHV IVALLPLLHI QPKETVAVFR YLIVENRDAV QDFLHEIYFL PDHPELKEIQ KVLQEYRKET TKSTDLQTAM QLSIRAIQHE NVDVRMHALT SLKETLYKNQ AKLLQYSTDS ETVEPVISQL VTVLLIGCQD ANPQARLFCG ECLGQLGAID PGRLDFSPSE TQGKGFTFVS GVEDSDFAYE LLTEQTRAFL AYADNVRAQD SAAYAIQELL SIFECKEGRT DCPGRRLWRR FPEHVQEILE PHLNTRYKSS RKAVNWSRVK KPIYLSKLGN NFADWSATWA GYLITKVRHE LARRVFSCCS IMMKHDFKVT IYLLPHILVY VLLGCNKEDQ QEVYAEIMAV LKHEDPLMRR LQDSASDLSQ LSTQTVFSML DHLTQWAREK FQALNAEKTN PKPGTRGEPK AVSNEDYGEY QNVTRFLDLI PQDTLAVASF RSKAYTRALM HFESFIMEKK QEIQEHLGFL QKLYAAMHEP DGVAGVSAIR KKEASLKEQI LEHESIGLLR DATACYDRAI QLKPEEIIHY HGVVKSMLGL GQLSTVITQV NGILNSRSEW TAELNTYRVE AAWKLSQWDL VEEYLSADRK STTWSIRLGQ LLLSAKKGER DMFYETLKVV RAEQIVPLSA ASFERGSYQR GYEYIVRLHM LCELEHSVKM FLQKPSVEPA VDSLNLPARL EMTQNSYRAR EPILAVRRAL QTINKRPNHA DMIGECWLQS ARVARKAGHH QTAYNALLNA GESRLSELNV ERAKWLWSKG DVHQALIVLQ KGAELFLSST SAPPEQQLIH GRAMLLVGRL MEETANFESN AVMKKYKDVT ALLPEWEDGH FYLAKYYDKL MPMVTDNKME KQGDLIRYIV LHFGRSLQFG NQYIYQSMPR MLSLWLDFGA KVYEWEKAGR ADRLQMKNEL MKINKVISDH KNQLAPYQFL TAFSQLISRI CHSHDEVFAV LMEIVAKVFV AYPQQAMWMM TAVSKSSYPM RVNRCKEILE KAIHMKPSLG KFIGDATRLT DKLLELCNKP VDGNTSTLSM NIHFKMLKKL VEETTFSEIL IPLQSVMIPT LPSTAGKRDH ADHDPFPGHW AYLSGFDDAV EILPSLQKPK KISLKGSDGK SYIMMCKPKD DLRKDCRLME FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGFRNIL IKLYKEKGIY MGGKELRQCM LPKSAPLQEK LKVFKEALLP RHPPLFHEWF LRTFPDPTSW YNSRSAYCRS TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV NGMGPMGTEG LFRRACEVIM RLMREQRESL MSVLKPFLHD PLVEWSKPAR GSSKGQVNET GEVMNEKAKT HVLDIEQRLQ GVIKTRNRVK GLPLSIEGHV HYLIQEATDE NLLSQMYLGW APYM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism.

Gene References into Functions

ATM activity is required for an early step in resection, leading to ATR activation, CtIP-T818 phosphorylation, and accumulation of CtIP on chromatin. PMID:23273981
Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP. PMID:16530042
interaction of the 9-1-1 complex (Rad9-Hus1-Rad1) with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR PMID:17636252

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Subcellular Location

Nucleus. Chromosome.

Protein Families

PI3/PI4-kinase family, ATM subfamily

Database Links

UNIGENE: Xl.718

KEGG: xla:398197

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