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Recombinant Xenopus laevis RAF proto-oncogene serine/threonine-protein kinase (raf1), partial

Recombinant Xenopus laevis RAF proto-oncogene serine/threonine-protein kinase (raf1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

raf1

Uniprot NO.

P09560

Alternative Names

raf1; raf; RAF proto-oncogene serine/threonine-protein kinase; EC 2.7.11.1; C-RAF

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-638

Target Protein Sequence

MEHIQGAWKT LSNGFGFKES VFEGSSCMSP TIVHQFGYQR RASDDGKLSD TSKTSSTMRV YLPNKQRTVV NVRSGMSLHD CLMKSLKVRG LQPECCAVFR LIQDPKGKLR LDWNTDAMSL VGAELQVDFL DHVPLTTHNF VRKTFLKLAF CDICQKFLLN AFRCQTCGYK FHEHCSTKVP TMCVDWSNIR QLLLFPNPNN IEGGSHTLPS LTMRRIGESV RIPVSSQQRY STPHPFSFST PSPVSECSLS QRQRSTSTPN VHMVSTTMAV DSRVIEDALR SHSESGSPNN LSPTGWSNAK APAPTHREKA ASSTGQEKNK IRARGQRDSS YYWEIIASEV MLSSRIGSGS FGTVYKGKWH GDVAVKILKV TDPTPEQLQA FRNEVAVLRK TRHVNILLFM GYMTKDNLAI VTQWCEGSSL YYHLHVLDTK FQMFQLIDIA RQTAQGMDYL HAKNIIHRDM KSNNIFLHEG LTVKIGDFGL ATVKTRWSGS QQVEQLTGSI LWMAPEVIRM QDNNPFSFQS DVYSYGIVLY ELMTGELPYS HIRDRDQIIF LVGRGGVVPD LSKLYKNCPK AMKRLVADSI KKLRDERPLF PQILSSIELL QHSLPKINRS ALEPSLHRAA HTEDISSCAL TSTRLPVF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).

Subcellular Location

Cytoplasm. Cell membrane.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily

Database Links

UNIGENE: Xl.5697

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