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Recombinant Xenopus laevis Protein kinase C beta type (prkcb), partial

Recombinant Xenopus laevis Protein kinase C beta type (prkcb), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

prkcb

Purity

>85% (SDS-PAGE)

Target Names

prkcb

Uniprot NO.

Q7LZQ8

Alternative Names

prkcb; prkcb1Protein kinase C beta type; PKC-B; PKC-beta; EC 2.7.11.13

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

2-671

Target Protein Sequence

SDSEACEPG DDTTTRFARK GALRQKNVHE VKEHKFTARF FKQPTFCSHC TDFIWGFGKQ GFQCQVCCFV VHKRCHEFVT FSCPGADKGP ASDDPRSKHK FRIHTYSSPT FCDHCGSLLY GLIHQGMKCE TCMMNVHKRC VMNVPSLCGT DHTERRGRIH IKAEIKEEVM TVTVGDAKNL VPMDPNGLSD PYVKLKLIPD PKSETKQKTK TIKCSLNPSW NETFKFQLKE SDKDRRLSVE IWDWELTSRN DFMGSLSFGI SELLKAGVDG WFKLLSQEEG EYFNVPVPPE GEEGNEELRQ KFERAKIGPG NKAAGREGGK PSVQGGQQGN RDHMKVSDFN FLKVLGKGSF GKVTLAERKG TDELYAIKIL KKDVVIQDDD VECTMVEKRV LALSGKPPFL THLHSCFQTM DRLYFVMEFV NGGDLMYQIQ QVGRFKEPHA VFYAAEIRVG LLFLHSKGIV YRDLKLDNVM LDSEGHIKIA DFGMCKENMW DGITTKTFCG TPDYIAPGII RYQPYAKSVD WWAFGILLYE MLAGHVPFEG EDEDELFQSI MEHNVAYPKS MSKEAVAICK GLMTKHPGKR LGCGPEGERD IKDHAFFRYI DWEKLERNEI QPPYKPKACG RNAENFDKFF TRHPPVLTPP DHEVIRNIDQ SEFEGFSYVN SDFSKEEEKK D
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation.

Subcellular Location

Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily

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