Recombinant Xenopus laevis Protein Wnt-11 (wnt11)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

wnt11

Purity

>85% (SDS-PAGE)

Target Names

wnt11

Uniprot NO.

Q670P5

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

23-352

Target Protein Sequence

IKWLALSK TPLSLPLNQT QHCKQLEGLV SSQMQLCRSN LELMQTIIHA AKEVKKTCVK AFTDMRWNCS SIELAPTFHQ DLERGTRESA FVHALSAAAI SHTIARACTT GDIPGCSCAP IPGESPGPGY RWGGCADNLN YGILMGSKFS DAPMKMKKSG SQANKLMHLH NSEVGRQVLK ASLEMKCKCH GVSGSCSIKT CWRGLQELRE IALDLKTKYL SATKVVHRPM GTRKHLVPKD IDIRPVQETE LIYLQSSPDY CLKNEKIGSH GTHERQCNKT SNGSDSCDLM CCGRGYNPYM DKVVERCLCK YHWCCYVTCK KCERTVERYV CK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Ligand for members of the frizzled family of seven transmembrane receptors. Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca(2+).

Gene References into Functions

Xenopus Wnt11-R is expressed in neural tissue, the brachial arches, and the muscle layer of the heart. PMID:15708567
Wnt11-R signaling regulates a calcium sensitive EMT event essential for dorsal fin development of Xenopus. PMID:17240368
wnt11r is required in a non-cell-autonomous manner to control neural crest migration. PMID:18942153

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Subcellular Location

Secreted, extracellular space, extracellular matrix.

Protein Families

Wnt family

Tissue Specificity

In embryos, expressed in the neural tube, dorsal somite, mesenchymal cells within the dorsal fin, branchial arches and heart muscle, becoming expressed throughout the myocardium by the tadpole stage (stage 45). Prior to neural crest cell migration, expres

Database Links

UNIGENE: Xl.13686

KEGG: xla:446915

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