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Recombinant Xenopus laevis Probable ATP-dependent RNA helicase DDX4 (ddx4), partial

Recombinant Xenopus laevis Probable ATP-dependent RNA helicase DDX4 (ddx4), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ddx4

Purity

>85% (SDS-PAGE)

Target Names

ddx4

Uniprot NO.

Q91372

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-700

Target Protein Sequence

MEENWDTEIE TEKPTYVPNF STLETENTDN YSAYSNNDIN NQNYDSERSF GNRGGYRSER SRPSNFNRGS RTERGRGRGF GTNRNDNYSS ERDVFGDDER DQRRGFPGRG GYNGNEDGQK PNAFRGRGGF RNENEQRRGF GERGGFRSEN GQRNFDNRGD FGNSGEEEDR PRSYGRGGFN NSDTGGRGRR GGRGGGSQYG GYKGRNEEVG VESGKSQEEG NEKDEKPKKV TYIPPPPPDG EDNIFRQYQS GINFDKYDEI LVDVTGKDVP PAILTFEEAN LCETLRRNVA RAGYVKLTPV QKHSIPIIMA GRDLMACAQT GSGKTAAFLL PILSYMMNEG ITASQYLQLQ EPEAIIIAPT RELINQIYLD ARKFSYGTCV RPVVVYGGIQ PVHAMRDVEK GCNILCATPG RLLDIVSKEK IGLSKLRYLV LDEADRMLDM GFAPEIEKLM TKPGMPTKEK RQTLMFSATY PEEIRRLASN YLKSEHLFVV VGLVGGACSD VAQTVLEMRE NGKMEKLLEI LKSSEKERTM IFVNTKKKAD FIAGYLCQEK FSSTSIHGDR EQYQRESALW DFRTGKCTVI VCTAVAARGL DIENVQHVIN YDVPKEVDEY VHRIGRTGRC GNTGKATSFF NVQDDHVIAR PLVKILTDAH QEVPAWLEEI AFGGHGALNS FYAADSMGEQ AGGNAVTTPS FAQEEEASWD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probable ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle.

Gene References into Functions

The RNA helicase Vasa is another essential protein in germline development and arginine methylation is conserved across phyla PMID:20080973
XVLG1 protein in pPGC is not sufficient to increase the number of primordial germ cells in the tadpoles PMID:14706067
Xdsg protein in pPGCs may play an important role in the formation of PGCs by regulating the production of XVLG1 protein PMID:16806152

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

DEAD box helicase family, DDX4/VASA subfamily

Tissue Specificity

An mRNA and protein component of germ plasm and primordial germ cells (PGCs). Doesn't appear to localize to the mitochondrial cloud of early oocytes. In contrast to its germ plasm localization, shows weak expression in the animal hemispheres of stage 1-5

Database Links

UNIGENE: Xl.256

KEGG: xla:398019

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