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Recombinant Xenopus laevis Platelet-derived growth factor subunit A (pdgfa)

Recombinant Xenopus laevis Platelet-derived growth factor subunit A (pdgfa)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

pdgfa

Uniprot NO.

P13698

Alternative Names

pdgfa; Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

92-226

Target Protein Sequence

SVEEAVPAI CKTRTVIYEI PRSQIDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRI HHRSVKVAKV EYVRKKPKLK EVLVRLEEHL ECTCTANSNS DYREEETGFF TSPALVLTGR TRETGKKQKR KKLKPT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Signaling is modulated by the formation of heterodimers with PDGFB.

Gene References into Functions

PDGF-A/PDGFRalpha signalling as a tissue-autonomous regulator of contact inhibition of locomotion by controlling N-cadherin upregulation during epithelial-to-mesenchymal transition. PMID:28526750
When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it. PMID:21205800

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Subcellular Location

Secreted.

Protein Families

PDGF/VEGF growth factor family

Database Links

UNIGENE: Xl.841

KEGG: xla:397765

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