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Recombinant Xenopus laevis Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (inpp5d), partial

Recombinant Xenopus laevis Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (inpp5d), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

inpp5d

Purity

>85% (SDS-PAGE)

Target Names

inpp5d

Uniprot NO.

Q6P4S2

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-1019

Target Protein Sequence

MSYGWYHGNI TRSKAEDLLS QAGKDGSYLV RDSESVCRAY ALCVLNQNCV HTYRILQNAE HQLSVQASEG VPMRFFTNLV ELIEFYRREN VGLVTHLQYP IEKEEEGPEE PDEEQEPAPP NVPPRNFAFT PPSETKECQT AIERAPAANA SLLLSETLLQ RFQDTDSRCI PEEHLQAICD YFSLHIVSDC DMVRTGSQTL PQFKKLLMTL CTGLHRELTR TLPTLESLQV AIDPQLSPGF KQRSPLPGDS ATNNMVNKLT HLTSMVSNLE EKVKTVLMEG AAVKHRRSLI PPIIFEVKAD SIGISQKTHL KVDVETGKLI IKKSKDGPDD KFYPSKKILQ LIKSQKFPHK LVIVLETEKE KTQRKEYVFA DSKKREGFCQ LLQQMKNKHS GQSEPDMLSI FIGTWNMGDA PPPKNITPWF QCKGQGKTRD DTADYIEHDI YVIGTQEDPL SEKEWTDTLI HSLREITSVE YKVITTQTLW NIRIVVLAKP EHAHRISHVC TNSVKTGIAN TLGNKGAVGA SFMFNGTSFG FINSHLTSGS EKKLRRNQNY FNILRFLVLG DKKLSPFNFT HRFNHLFWLG DLNYRLQLPN TEAENIIQKI KQQQHQELLP HDQLNLERRE SLIFFQFHEE EITFPPTYRY ERGSRERYCY TKQKATGIKY NLPSWCDRIL WKSYPQMHIL CQSYGCTDDI TTSDHSPVFG TFQVGVTSQF VSKNNPGDSG DLEAQGHIEL MNCKATLYTK SHTKFYIEFH SPCLENMVKS SEAEDQEGNN GTLVVKFGVL PKLTPIISDL EYLLDQHLLI CIKSSDTDES YGEGCIALRK EDTEQQFPFC TILTHHGEET GLFCGEICLP ASGGKQREKL YDFVKIEKDE TVAQKQLKHP YSQSMEQSRI MKSISEKSAM IARMRAAPET QNSMDHTASV AAISSQAKQS PPTTPPGFRG SEPRQKPGSP VQGRGDTPIT SPPRTTLSTQ KFSHSNTNRT APAARPQDSL QITVPSDPHE MVDNPLYGPV NNTLYPPTA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells.

Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton.

Protein Families

Inositol 1,4,5-trisphosphate 5-phosphatase family

Database Links

UNIGENE: Xl.34826

KEGG: xla:399051

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