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Recombinant Xenopus laevis Paired box protein Pax-8 (pax8)

Recombinant Xenopus laevis Paired box protein Pax-8 (pax8)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

pax8

Purity

>85% (SDS-PAGE)

Target Names

pax8

Uniprot NO.

Q9PUK5

Alternative Names

pax8; pax-8Paired box protein Pax-8; XPax-8

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-465

Target Protein Sequence

MPNSSIRSEL TTERGFSGPA SNFNIGHGGL NQLGGAFVNG RPLPEVVRQR IVDLAHQGVR PCDISRQLRV SHGCVSKILG RYYETGSIRP GVIGGSKPKV ATPKVVEKIG DYKRQNPTMF AWEIRDRLLT DGVCDNDTVP SVSSINRIIR TKVQQLFNLP MESCVKSLSP GQTLIPSSTV TPPESPHSDS LGSTYSISGL LGITQPSADG KRKLDDSDQE SCRLSIDSQG SVGISRKQLR TEAYGHHPLD ALECHFQRQH FPESYSSSTH SKTEQALYTL PLLNISLDDG KSSLTSTNTT IGRNLSTHQG YSALSEFTAF SIKQEASDSS SASSTPSSLC SPTFLDLQPI NSGCSAPSFS AFSHPSVYGQ FTSHVASGRD VVGATLPGYP PHIPSGQGNY ASSAIAGMVA AGGDYSANAY SHGAYAAYGD SWRFPSSSLL GSPYYYSSGT RTAPPPTTAG AYDLM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 to establish the pronephric primordium in late gastrulae/early neurulae.

Gene References into Functions

Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b and wnt pathway genes in the kidney field. PMID:25446030
nephrogenic transcription factors (osr1, osr2, hnf1b, lhx1, pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A, retinoic acid PMID:21281489

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Subcellular Location

Nucleus.

Tissue Specificity

Expression starts at late gastrula stages in cells fated to become the primordia of the otic system and the pronephric kidney. Expression is maintained in these two structures through late tailbud stages. Does not appear to be expressed in the thyroid gla

Database Links

UNIGENE: Xl.2754

KEGG: xla:398132

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