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Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial

Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

notch1

Uniprot NO.

P21783

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Gene References into Functions

Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3 PMID:21610033
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline. PMID:21276789
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 gene or the constitutively active form of Notch (IC). PMID:21194527
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. PMID:20547764
results suggest that a cell-to-cell interaction via the Notch/Su(H) pathway has a significant role in the PGC migration by regulating cell motility PMID:20151992
the process of delimiting the three germ layers requires Notch signaling. PMID:20079726
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis PMID:15172688
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells. PMID:15300513
Notch controls smad2 nuclear localization and the competence of ectodermal cells for activin A in Xenopus embryos PMID:15817224
Notch signaling has a role during the prepatterning of the cardiac mesoderm PMID:19580804