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Recombinant Xenopus laevis Neurogenic differentiation factor 1 (neurod1)

Recombinant Xenopus laevis Neurogenic differentiation factor 1 (neurod1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

neurod1

Purity

>85% (SDS-PAGE)

Target Names

neurod1

Uniprot NO.

Q91616

Alternative Names

neurod1; neurod; Neurogenic differentiation factor 1; NeuroD1

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-352

Target Protein Sequence

MTKSYGENGL ILAETPGCRG WVDECLSSQD ENDLEKKEGE LMKEDDEDSL NHHNGEENEE EDEGDEEEED DEDDDEDDDQ KPKRRGPKKK KMTKARVERF KVRRMKANAR ERNRMHGLND ALDSLRKVVP CYSKTQKLSK IETLRLAKNY IWALSEILRS GKSPDLVSFV QTLCKGLSQP TTNLVAGCLQ LNPRTFLPEQ SQDIQSHMQT ASSSFPLQGY PYQSPGLPSP PYGTMDSSHV FHVKPHSYGA ALEPFFDSST VTECTSPSFD GPLSPPLSVN GNFTFKHEHS EYDKNYTFTM HYPAATISQG HGPLFSTGGP RCEIPIDTIM SYDGHSHHER VMSAQLNAIF HD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a transcriptional activator. Plays a role as a differentiation factor during neurogenesis. Required for the conversion of cells within the neural plate and ventral ectoderm into differentiated neurons. Promotes the differentiation of late-born retinal amacrine cells, but not early-born retinal ganglion cells. Its function is inhibited at early stages of retinal cells differentiation.

Gene References into Functions

Premature misexpression of NeuroD1 in chick partially recapitulates the amphibian condition by suppressing transit amplification. PMID:25005474
NeuroD1 gene activity is turned on in new born neurons during post-metamorphic neurogenesis. PMID:23799108
NeuroD promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation. PMID:22491944
This study reveals that the early larval stage in Xenopus (Stage 48) displays patterns of proliferation (NeuroD). PMID:16025451
Data demonstrate that Neurogenin and NeuroD preferentially recognize neurogenesis-related targets through an enhancer signature of clustered consensus-binding sites and regulate neurogenesis by activating a core set of transcription factors. PMID:18007592