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Recombinant Xenopus laevis Mitotic spindle assembly checkpoint protein MAD2B (mad2l2)

Recombinant Xenopus laevis Mitotic spindle assembly checkpoint protein MAD2B (mad2l2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

mad2l2

Purity

>85% (SDS-PAGE)

Target Names

mad2l2

Uniprot NO.

Q8QFR4

Alternative Names

mad2l2; mad2B; mad2l2-aMitotic spindle assembly checkpoint protein MAD2B; Mad2l2-A protein; Mitotic arrest defective protein 2B; Mitotic arrest deficient 2-like protein 2; MAD2-like protein 2; xMAD2L2

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-211

Target Protein Sequence

MTTLTRQDLN FGQVVADILC EFLEVAVHLI LYVREVYPTG IFQKRKKYNV PVQMSCHPEL NRYIQDTLHC VKPLIEKNDV EKVVVVILDK EHHPVERFVF EIAQPPLLSI SSDSLLSHVE QLLRAFILKI SVCDAVLDNN PPGCTFTLLV HTREAATRNM EKIQVIKDFP WILADEQDVH MQEPRLIPLK TMTSDILKMQ LYVEERAQKS T
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation.; Inhibits the fzr1-APC complex activity during mitosis. Plays a role in progression of mitosis.

Gene References into Functions

We have successfully isolated Xenopus laevis Mad2B and PRCC cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC and xMad2B in the intricate processes of cell cycle control. PMID:15218244

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Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.

Database Links

UNIGENE: Xl.8200

KEGG: xla:394380

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