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Recombinant Xenopus laevis Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (pkmyt1), partial

Recombinant Xenopus laevis Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (pkmyt1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

pkmyt1

Purity

>85% (SDS-PAGE)

Target Names

pkmyt1

Uniprot NO.

Q91618

Alternative Names

pkmyt1; myt1; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; EC 2.7.11.1; Myt1 kinase

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-548

Target Protein Sequence

MPVPGDDMGE TPLTRTPIPM PAYFSQAEQS FSLKKRGRSL CYTLPPRPPV KSALPVSRIF PNKQRSWSQP RPQSVSFRSP QNKTPASKLY DQSKGDTFFK QCFKSICKLG RGSFGEVYKV QSLEDGCFYA VKRSVSPFRG ESDRQRKLQE VRKHERVGEH PNCLRFVRAW EEKRMLYLQT ELCAGSLQQH SEEFAGSLPP RRVWNITCDL LHGLKHLHDR NLLHLDIKPA NVFISFSGVC KLGDFGLMVE LDGTEGSGEA QEGDPRYMAP ELLDGIFSKA ADVFSLGMSL LEVACNMELP KGGDGWQQLR QGHLPTEFTS DLPPDFLKVL SAMLEPDYRR RATVDWLLSL PAIRNAERWR MVTLAQERTL GKIIAVYQFI VWLLSFVFQW LNRPVIGFLH YCGLRALPRS PPCSPFPNHL GESSFSSDWD DESLGDDVFE VPPSPLATHR NLTYHGQELI GRHSPDLLSR PSLGSTSTPR NLSPEFSMRK RSALPLTPNV SRISQDSTGK SRSPSTSHSS SGFVDAEVQR TLFLPRNLLG MFDDATEQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene References into Functions

Data show that CDK1 and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression. PMID:20362450
Study propose a model in which the appearance of active MPF complexes following increased Cyclin B synthesis causes Myt1 inhibition, upstream of the MPF/Cdc25 amplification loop. PMID:21795279
Autophosphorylation of Myt1 is a novel inhibitory mechanism that adds another layer of complexity to the phosphorylation-dependent mechanism of Myt1 regulation. PMID:16481744
XRINGO-activated CDKs can phosphorylate specific residues in the regulatory domain of Myt1. PMID:18951089