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Recombinant Xenopus laevis Inhibitor of nuclear factor kappa-B kinase subunit alpha (chuk), partial

Recombinant Xenopus laevis Inhibitor of nuclear factor kappa-B kinase subunit alpha (chuk), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

chuk

Purity

>85% (SDS-PAGE)

Target Names

chuk

Uniprot NO.

Q6GM53

Alternative Names

chuk; ikkaInhibitor of nuclear factor kappa-B kinase subunit alpha; I kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-743

Target Protein Sequence

MERPPVQHGA VCGPWDMKDR LGTGGFGNVC LYQNRETGEL KAIKSCRLEL SVKNKERWCQ EIQIMKRLNH PNVVKACDVP PEMDFLVNDV PHLAMEYCAG GDLRKLLNKP ENCCGLKESQ VLNLISDIGS GIQYLHENRI IHRDLKPENI VLQECNGKTV HKIIDLGYAK DLDQGSLCTS FVGTLQYLAP ELFENKPYSV TVDYWSFGTM AFECIAGFRP FLHNMQPFTW HEKIKKKDHK HIYAYEEMSG EIRFSTSLPE PNNLCSIIVD KIETWLQLLL NWDPVQRGGG IDCGRPRCFM LMDQIFSLKI VHILNMTSAK IHSFHLQPEE SLHTLQSRIE RETGISTCNQ ELLLEMGVSL DPRKPASQCV IDGVKGWDSY MVYLFDKSKT VYEGPFQSRS LSECLNYIVQ DSKVQLPIPQ LRKVWAEAVH YVSGLKEDYS RLFQGQRAAM LSLLRFNTNL TKMKNTMVSA SQQLDAKLQF FKRSIEIDLE RYSDQMAYGI SSEKMLRAWK EMEDKAVCFG KAGEIHFLDE TIMGLHTEIV ELQRSPCARR QGDVMEHLEQ RAMELYKQLK PRSPDKAYSD STEMVKILVQ TVQGQDRVLK ELFGHLSKLL GCKQKIIDLL PQIEMTVNNI KEADSSLMQM QAKRQREIWH LLKIACTQSS TRSLVTASGE TPITSRTSAW SDQSSPQALF SMLTSKDKGR EILRHTIDKN TDYQKLLSNL ILQTQTTMEQ TSLMSMDFSW LNQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily

Database Links

UNIGENE: Xl.31871

KEGG: xla:444556

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