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Recombinant Xenopus laevis Forkhead box protein O3 (foxo3), partial

Recombinant Xenopus laevis Forkhead box protein O3 (foxo3), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

foxo3

Purity

>85% (SDS-PAGE)

Target Names

foxo3

Uniprot NO.

Q6EUW1

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-657

Target Protein Sequence

MAEALPPRSP PDDVDIDPDF GPQSRPRSCT WPLQRLDSQG SPGKPNSGAG EAADTSSMIP EEEDDDYEGA ASTATVLGTA GDKGTLVLLS GGESGQLAVL ASPVGGVETL QVSLGGEGAG GAVSGAGGQQ QQRKCSSRRN AWGNMSYADL ITRAIESTQD KRLTLSQIYD WMVRSVPYFK DKGDSNSSAG WKNSIRHNLS LHSRFIRVQN EGSGKSSWWM INPEGGKGGK APRRRAVSMD NSNKYTKSRG RAAKKKASLQ ASSDATDDSP SQLSKWPGSP TSRSSDKLDT WTDFRSRTNS NASTISGRLS PIPATTELDD VQDDDSPLSP MLYNSPGSLS PSISKPCTVE MPRITDMAET MNLNDGLPEN LMDDLLDDIS LTSSQQSSPG VLMQRSSSFT YGTKGSGIGS PSNNFNNTGS FNFPLTSLRQ SPMQTIQENK QATFSSMNHY SNQSLQDLLN TDTLSHSDVL MTQSDPLMSQ ASTAVTAQNS RRNIILRNDP MMSFAAQPNQ GGNLVNQNSL HQQQSLNSFQ GGSRALSNNL SNTGLNDSSI LESTKHQQQS SVSHSMQTIS DTLSGSLYSS GVTLPTLGHE KFPTDLDLDI FNGSLECDME TIIRNDLMDA DGLDFNFDTL ISAQNVSLSV GSFTGAKQTS SQSWVPG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins. Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Also acts as a key regulator of regulatory T-cells (Treg) differentiation.

Subcellular Location

Cytoplasm, cytosol. Nucleus.

Tissue Specificity

Localized to the animal hemisphere during early cleavage stages. At the late neurula, localized in the anterior neural plate, neural crest cells and in the hatching gland. As development progresses, expression becomes less localized, being observed in a v

Database Links

UNIGENE: Xl.2074

KEGG: xla:444992

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