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Recombinant Xenopus laevis Forkhead box protein O1 (foxo1), partial

Recombinant Xenopus laevis Forkhead box protein O1 (foxo1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

foxo1

Purity

>85% (SDS-PAGE)

Target Names

foxo1

Uniprot NO.

Q6EUW2

Alternative Names

foxo1; foxo1aForkhead box protein O1; FoxO1; xFoxO1; FoxO1A

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-631

Target Protein Sequence

MAEAPQPPPP LVEIDPDFEP FSRPRSCTWP LPRPEFNPSS SANSSPAPSL QPEPAAGNVD FLSNLSLLEE SEDFDPAEAL GVCGDFPCQD IRQLQPPIPQ QQQQHSQQQQ EALTLLAPSV PSALSPASSP SPLGAQQPRK SSSSRRNAWG NLSYADLISQ AIESSPEKRL TLSQIYDWMV KSVPYFKDKG DSNSSAGWKN SIRHNLSLHS KFVRVQNEGT GKSSWWILNP EGGKNGKSPR RRAASMDNNS KFAKSRGRAA KKKASMQSSQ DGSSDSPGSQ FSKWPGSPSS QSNDDFEAWS TFRPRTSSNA STISGRLSPI MPEQDDLGDA DVHNLVYPSS ATKLTSTLPS LSEMGNSENM ENLLDNLNLL TPNSSTQSSP ASMMQQSGYL FTSPNTSLGS PNSEYRKYSY AQTGISPISQ MPMQTVPENK SGYRAVGQYP VPAGLLKELL TSDSPPHNDI LTPVDPAVSQ ANNRVLGQNS LIGSNSIMPA YGSQPAPNKM SSHPHLHQPN HPTSINGRPI AHNPGINRLS TVKTSVQVPM PHQPIQMTSM GSYSMNSCNG YGRVGIVSIH QEILPSDLDD MLIESLDCDV ESIIRNDLME DGEADFNFDS ILPNQSFPHS VTTTTHSWVS G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that regulates metabolic homeostasis in response to oxidative stress. Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with atf4 to suppress osteocalcin/bglap activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of runx2, an upstream activator of osteocalcin/bglap.

Gene References into Functions

FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase and catalase mRNA and protein levels in this organ. PMID:21708231

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Localized to the animal hemisphere during early cleavage stages. At early tadpole stages, expressed in the branchial arches, pronephros and liver. Within the head, expressed in the forming thyroid gland and in head mesenchyme anterior to the eyes.

Database Links

UNIGENE: Xl.48324

KEGG: xla:444991

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