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Recombinant Xenopus laevis Double-strand break repair protein MRE11 (mre11), partial

Recombinant Xenopus laevis Double-strand break repair protein MRE11 (mre11), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

mre11

Purity

>85% (SDS-PAGE)

Target Names

mre11

Uniprot NO.

Q9W6K1

Alternative Names

mre11; Double-strand break repair protein MRE11; EC 3.1.-.-

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-711

Target Protein Sequence

MSSSSSSLDD EDTFKILVAT DIHLGFMEKD AVRGNDSFVA FDEILRLAQD NEVDFLLLGG DLFHDNKPSR RTLHICLEQL RKYCMGDRPI EFEVLSDQSV NFGYSKFPWV NYQDNNLNIS LPVFSVHGNH DDPTGADALC ALDILSSAGL VNHFGRATSV EKIDISPVLL QKGHSKIALY GLGSIPDERL YRMFVNKQVM MLRPREDESS WFNLFVIHQN RSKHGPTNYI PEQFLDEFLD LVIWGHEHEC KIAPTRNEQQ LFYVSQPGSS VATSLSPGEA EKKHVGLLRI KGKKMNMQKI PLQTVRQFFI EDLVLSDYPD IFNPDNPRVT QEIETFCIEK VEAMLDTAER ERLGNPRQPD KPLIRLRVDY TGGFEPFNTL RFSQKFVDRT ANPKDIIHFF RHKEQKDKKD SITINFGKID SKPLLEGTTL RVEDLVKEYF KTAEKNVQLS LLTERGMGEA VQEFVDKEEK DALEELVKFQ LEKTQRFLKE RHIDAEEEKI DEEVRKFRET RKTNTNEEDE EVREAIQRAR THRSQAPDVE MSDEDDDALL RKVSLSDDED VRASMPARGR GRGRARGGRG QSTTTRGTSR RGRGSASADQ PSSGRATKAT GKNMSILDAF KPSSRQPTAR NVAKKTYSED IEDDDSDLEE VSFTPSSVIE SRRTSSTSTS YSRKSTQPQS QATKAHFFDD DDDEEDFDPF KKSGPSRRGR R
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Gene References into Functions

these findings suggest that the structure of ends is a major determinant for the pathway choice of DSB repair and the Mre11 nuclease dependency of resection. PMID:27084932
MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends. PMID:26880199
these data point to Mre11 as an important locus of Rsk-mediated checkpoint inhibition acting upstream of ATM activation. PMID:24297933
The MRN complex, in particular the nuclease activity of Mre11, plays an important role in the activation of Chk1 in response to stalled replication forks. PMID:23468519
MRN (MRE11-RAD50-NBS1) complex has role in ATR activation via TOPBP1 recruitment. PMID:23582259
Results indicate a role for the X. laevis Mre11/Rad50/Nbs1 complex in microhomology-mediated end joining. PMID:19892829
Mre11 has a role in assembling DNA damage signaling centers PMID:15138496
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1-dependent activation of ATR-ATRIP in response to double-stranded DNA breaks. PMID:19279141