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Recombinant Xenopus laevis Bone morphogenetic protein 7 (bmp7)

Recombinant Xenopus laevis Bone morphogenetic protein 7 (bmp7)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

bmp7

Uniprot NO.

P30886

Alternative Names

bmp7Bone morphogenetic protein 7; BMP-7; xBMP7; Osteogenic protein 1; OP-1

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

283-426

Target Protein Sequence

STSNKHWN QERAKTYKEQ DNLPPANITD GIMPPGKRRF LKQACKKHEL FVSFRDLGWQ DWIIAPEGYA AYYCDGECAF PLNSFMNATN HAIVQTLVHF INPETVPKPC CAPTQLNGIS VLYFDDSANV ILKKYKNMVV QACGCH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

Gene References into Functions

Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation. PMID:15975940

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Subcellular Location

Secreted.

Protein Families

TGF-beta family

Database Links

UNIGENE: Xl.3326

KEGG: xla:379625

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