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Recombinant Tetraodon miurus Cellular tumor antigen p53 (tp53)

Recombinant Tetraodon miurus Cellular tumor antigen p53 (tp53)

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

tp53

Uniprot NO.

Q9W679

Species

Tetraodon miurus (Congo puffer)

Source

Yeast

Expression Region

1-367

Target Protein Sequence

MEEENISLPL SQDTFQDLWD NVSAPPISTI QTAALENEAW PAERQMNMMC NFMDSTFNEA LFNLLPEPPS RDGANSSSPT VPVTTDYPGE YGFKLRFQKS GTAKSVTSTY SEILNKLYCQ LAKTSLVEVL LGKDPPMGAV LRATAIYKKT EHVAEVVRRC PHHQNEDSAE HRSHLIRMEG SERAQYFEHP HTKRQSVTVP YEPPQLGSEF TTILLSFMCN SSCMGGMNRR PILTILTLET QEGIVLGRRC FEVRVCACPG RDRKTEETNS TKMQNDAKDA KKRKSVPTPD STTIKKSKTA SSAEEDNNEV YTLQIRGRKR YEMLKKINDG LDLLENKPKS KATHRPDGPI PPSGKRLLHR GEKSDSD

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

P53 family

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