Recombinant Sparus aurata Interleukin-6 (il6)

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

il6

Uniprot NO.

B6CKP4

Species

Sparus aurata (Gilthead sea bream)

Source

Yeast

Expression Region

25-225

Target Protein Sequence

APVDGA FTDNPAGDTS GEEWETERPA DPLIALLKVV LEVIKTHRQE FEAEFHIRYD VLAQYNIPSL PADCPSTNFS MEALLHRLLQ GLPVYTALLK YVEKEEPKSQ IPSRFRQNSE LLKQRITGKM RHAVQVTPLT SSQEQQLLRD LDSSDTFHRK MTAHSILYQL RSFLVDCKNA INKKEKLRES RANRAMTPVT LYYQS

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.

Subcellular Location

Secreted.

Protein Families

IL-6 superfamily

Tissue Specificity

Expressed in white muscle, skin, spleen, anterior intestine and stomach. Not expressed in brain, gill, head kidney, posterior intestine and adipose tissue.

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