Home
Product
Protein
Recombinant Proteins
Recombinant Sheep Vascular endothelial growth factor A (VEGFA)

Recombinant Sheep Vascular endothelial growth factor A (VEGFA)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

VEGFA

Uniprot NO.

P50412

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

27-146

Target Protein Sequence

APMA EGGQKPHEVM KFMDVYQRSF CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEK CDKPRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.

Gene References into Functions

Data show that both short- and long-term exposure to high-altitude conditions decreased luteal growth and IGF-I and IGF-II gene expression but increased HIF-1 alpha and VEGF immunoexpression. PMID:23521851
The objective of the study was to determine the expression of vascular endothelial growth factor (VEGF-A), tyrosine kinase receptors Flt-1 and KDR and KDR co-receptor neuropilin 1 (NRP-1) in ovine choroid plexus during different photoperiods. PMID:22622803
In this model of smoke inhalation and pneumonia induced acute lung injury, overexpression of VEGF in lung tissue occurred, potentially contributing to increased transvascular fluid and protein flux. PMID:22647495
Arterial smooth muscle cells are organized into lamina of similar phenotype with characteristics that depend on the position between the lumen and the adventitia and involve the direct effects of VEGF on smooth muscle in an age-dependent manner. PMID:21653901
This demonstrates the importance of adaptation of cell signaling over endothelial nitric oxide synthase expression in pregnancy adaptation of uterine endothelial function and further implicates VEGF-A in the pathophysiology of preeclampsia. PMID:21239633
VEGF-A expression showed a clear trend of increasing levels, but these did not reach significant differences in the chronic heart failure group compared to the control group. PMID:21092039
observations support the hypothesis that vascular endothelial growth factor A regulates amniotic fluid transport across the amnion by stimulating caveolin-1 activity to mediate caveolar function in amnion cells PMID:20720263
These findings indicate that outside stenting of the vein graft decreases VEGF-A expression and induces significant down-regulation of VEGFR-1 in the intima and media after the re-endothelialization. PMID:20190677
The pattern of the rise in NOx in circulating plasma was not directly associated with changes in VEGF regardless of the number of fetuses present. PMID:15774525
it was concluded that vascular endothelial growth factor (VEGF) is likely to promote fetal lung expansion-induced endothelial cell proliferation PMID:16930512
Intrauterine pulmonary hypertension(PPHN) causes reduced pulmonary artery endothelial cell(PAEC) growth and tube formation and down-regulation of VEGF and eNOS. VEGF and NO enhanced growth and tube formation of PPHN PAECs. PMID:17823355
Reduced fetal and placental weights in twins and/or triplet pregnancies are associated with an overall decrease in total placental vascularity, VEGF and FGF2 and/or FGFR protein expression. PMID:18392787