Recombinant Sheep Pro-opiomelanocortin (POMC)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

POMC

Uniprot NO.

P01191

Alternative Names

POMCPro-opiomelanocortin; POMC; Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma; Gamma-MSH); Corticotropin; Adrenocorticotropic hormone; ACTH); Melanocyte-stimulating hormone alpha; Alpha-MSH; Melanotropin alpha); Corticotropin-like intermediary peptide; CLIP); Lipotropin beta; Beta-LPH); Lipotropin gamma; Gamma-LPH); Melanocyte-stimulating hormone beta; Beta-MSH; Melanotropin beta); Beta-endorphin; Met-enkephalin]

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

1-52

Target Protein Sequence

PDLSAETPVF PGNCDEQPLT ENPRKYVMGH FRWDRFGRRN GSSSFGAGGA AQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Stimulates the adrenal glands to release cortisol.; Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; Increases the pigmentation of skin by increasing melanin production in melanocytes.; Endogenous orexigenic opiate.; Endogenous opiate.

Gene References into Functions

Exon 3 of gene POMC was associated with growth traits. PMID:24400483
These epigenetic changes in GR and POMC in the hypothalamus may also predispose the offspring to altered regulation of food intake, energy expenditure, and glucose homeostasis later in life. PMID:20573728
Data show that reciprocal connections exist between kisspeptin cells and NPY and POMC cells. PMID:20207832
the fetal paraventricular hypothalamic nucleus is necessary for sustaining adequate anterior pituitary processing of POMC to ACTH and ACTH release needed for maturing the adrenal cortex in the sheep fetus. PMID:15718276
steroid-induced changes in GnRH release in the female sheep are associated with changes in the cellular mRNA content of the precursors for beta-endorphin (pro-opiomelanocortin; POMC) and met-enkephalin PMID:17151352
Neuropeptide Y, agouti-related peptide, proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), and insulin receptor mRNAs were all localized in the hypothalamic arcuate nucleus (ARC) of all fetuses. PMID:18417651
Long-term hypoxia enhances ACTH response to arginine vasopressin but not corticotropin-releasing hormone in the near-term ovine fetus. PMID:19625690