Recombinant Sheep Pro-neuropeptide Y (NPY)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NPY

Uniprot NO.

P14765

Alternative Names

NPY; Pro-neuropeptide Y [Cleaved into: Neuropeptide Y; Neuropeptide tyrosine; NPY); C-flanking peptide of NPY; CPON)]

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

29-64

Target Protein Sequence

YP SKPDNPGDDA PAEDLARYYS ALRHYINLIT RQRY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Gene References into Functions

NPY expression increases in the medial basal hypothalamus and arcuate and periventricular nuclei following fasting or intracerebroventricular (ICV) ghrelin infusion. PMID:23085194
Changes in the neuronal activity of hypothlamic arcuate NPY neurons between the prepubertal and peripubertal periods indicate that these neurons could be involved in mechanisms leading to puberty. PMID:20637857
The simultaneous increase of expression of hypothalamic NPY suggests NPY involvement in the regulation of psychoemotional stress through the somatotrophic axis in the female lambs. PMID:20675289
Data show that reciprocal connections exist between kisspeptin cells and NPY and POMC cells. PMID:20207832
results suggest that Neuropeptide Y (NPY) acts on the luteal vascular system and the large luteal cells to rapidly stimulate blood flow and the secretion of oxytocin implying a role for NPY in luteolysis PMID:19782503
NPY-ir neurons present in the infundibular nucleus can play a role in the preovulatory GnRH discharge from the median eminence PMID:16584086
Neuropeptide Y, agouti-related peptide, proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), and insulin receptor mRNAs were all localized in the hypothalamic arcuate nucleus (ARC) of all fetuses. PMID:18417651