Recombinant Sheep Natriuretic peptides B (NPPB)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NPPB

Uniprot NO.

O46541

Alternative Names

NPPBNatriuretic peptides B; Gamma-brain natriuretic peptide) [Cleaved into: Brain natriuretic peptide 29; BNP-29); Brain natriuretic peptide 26; BNP-26)]

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

27-129

Target Protein Sequence

HPLG GPGSASELPG LQELLDRLRD RVSELQAEQL RVEPLQQGQG LEETWDSPAA APAGFLGPHH SLLQALRGPK MMRDSGCFGR RLDRIGSLSG LGCNVLRRY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.

Gene References into Functions

ANP and BNP plasma concentrations are sourced from a single organ (the heart) and are subject to substantial extraction across most tissue beds in experimental heart failure. PMID:16095755
In a model of congenital cardiac defect with increased pulmonary blood flow, soluble guanylate cyclase alpha (sGCalpha) was greater at 2 & 4 weeks, & sGCbeta & phosphodiesterase 5 (PDE5) were greater at 4 weeks; plasma BNP increased. PMID:17902145

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Subcellular Location

Secreted.

Protein Families

Natriuretic peptide family

Database Links

UNIGENE: Oar.19888

KEGG: oas:100294642

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