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Recombinant Sheep Estrogen receptor beta (ESR2), partial

Recombinant Sheep Estrogen receptor beta (ESR2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ESR2

Purity

>85% (SDS-PAGE)

Target Names

ESR2

Uniprot NO.

Q9TU15

Alternative Names

ESR2; NR3A2Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

1-527

Target Protein Sequence

MDVKNSPSSL NSPVSYNCGQ SILPLEPGPI YLPSSYVESR HEYSAVTFYS PAVMNYSIPN NSEDGPGRQT TSPNVLWPTP GHLSPLAIHC QSSLLYAEPQ KSPWCETRSL EHTFPVNRET LKRKASGSSC ASPVSSPSSK RDAHFCAVCS DYASGYHYGV WSCEGCKAFF KRSIQGHNDY ICPATNQCTI DKNRRKSCQA CRLRKCYEVG MVKCGSRRER CGYRIVRRQR NSDEQLHCLS KTKRNGAPMT RVKELLLSAL SPEQLVLTLL EAEPPHVLMS RPSAPFTEAS MMMSLTKLAD KELVHMISWA KKIPGFVELS LYDQVRLLES CWLEVLMVGL MWRSIDHPGK LIFAPDLVLD RDEGKCVEGI LEIFDMLLAT TSRFRELKLQ HKEYLCVKAM ILLNSSMYPS ATASQEADSG RKLTHLLNAV TDALVWVIAK SGMSSQQQSM RLANLLMLLS HVRHASNKGM EHLLNMKCKN VVPVYDLLLE MLNAHTLRSN KPLVTRSERN LAEDSESKEG SQKPQAQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

Gene References into Functions

In uterine artery endothelial cells: 1) eNOS phosphorylation changes occur via ER-alpha- and ER-beta-dependent mechanisms and 2) ER-alpha and ER-beta can both increase NO levels independently from each other. PMID:27170438
Numerous ERbeta-immunoreactive cells were located throughout the hypothalamus and, following dual-label immunocytochemistry, over 50% of the GnRH neurones were found to express immunoreactive ERbeta PMID:15720473
ERalpha and ERbeta mRNA and protein are expressed in UA endothelium with expression levels depending on the endocrine status of the animal. PMID:15774511
Moreover, the high expression of both 17beta-HSD type 12 and ERbeta in breast carcinoma cells may play a role in the development and/or progression of breast cancer. PMID:16930994
estrogen receptor 1 and 2(ESR1 and ESR2) mediate feedback of estradiol(E2) on secretion of LH PMID:17429013
The expression of ER-alpha and ER-beta in the brain and pituitary of fetal sheep are influenced by circulating estrogen concentrations and acutely regulated in response to cerebral hypoperfusion. PMID:18160819
Ontogeny of ERB and its co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation is reported. PMID:18204852