Recombinant Sheep Endothelin-1 (EDN1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

EDN1

Purity

>85% (SDS-PAGE)

Target Names

EDN1

Uniprot NO.

Q9BG76

Alternative Names

EDN1Endothelin-1; ET-1; Preproendothelin-1; PPET1) [Cleaved into: Big endothelin-1]

Species

Ovis aries (Sheep)

Source

Yeast

Expression Region

53-73

Target Protein Sequence

CSCSSLMD KECVYFCHLD IIW
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.

Gene References into Functions

These results support the hypothesis that chronic hypoxia elicits sustained changes in fetal cerebrovascular reactivity to ET-1 through pathways dependent upon PKC, CaMKII, and p38 that cause increased ET-1-mediated contractility, decreased ET-1-mediated smooth muscle hypertrophy, and a depressed ability of ET-1 to promote contractile dedifferentiation. PMID:28566491
Endothelin receptor A, but not endothelin receptor B, mediates antisteroidogenic actions of endothelin 1 (EDN1) on prostaglandin (PGF2alpha)-induced luteolysis(endothelin 1). PMID:18077801
Study shows that ET-1 stimulates protein kinase Cd (PKCd) activity, which in turn attenuates eNOS transcription and NOS signaling through the activation of STAT3. PMID:19754268
Endothelin-1 has a role in reactive oxygen species production by pulmonary artery endothelial cells, leading to pulmonary artery endothelial cell dysfunction in congenital diaphragmatic hernia PMID:25580737
ET-1 decreases PPARgamma signaling and contributes to pulmonary artery endothelial cell dysfunction and impaired angiogenesis in persistent pulmonary hypertension of the newborn. PMID:24337925
Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. PMID:23202724
ET-1 stimulates ciliary beat frequency via interaction with endothelin A receptors; inhibition of both COX and NOS inhibited the effect of ET-1 suggesting a role for both enzymes in the ET-1 response downstream from the ETA-receptor PMID:21664477