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Recombinant Schizosaccharomyces pombe Tuberous sclerosis 2 protein homolog (tsc2), partial

Recombinant Schizosaccharomyces pombe Tuberous sclerosis 2 protein homolog (tsc2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

tsc2

Purity

>85% (SDS-PAGE)

Target Names

tsc2

Uniprot NO.

Q9UUG9

Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Source

Yeast

Expression Region

1-1339

Target Protein Sequence

MNNKSLLDLS SEPAIKDTDI LSYFDANLPF KKRHQIVRSI YHGLKYYIYS STSIIQVWQN IQDFISTKND NAAFRELVYN LMMRYVSTQK HLSIIERHTF FQTIEKDPFQ DIAELQLRLK SLSVLTDEGH KISGIENRVG PLLSAWFNQY LQWQSQATEL QGKDADSKLV HLLFFKSLFK FSTNLVKFQW FLVPEPQMLQ LVNSVVQICN HARLEDVVTE VLMFFDSMIR YSVIPKASLY DTVLILCSTY ISTYSYSKLA QSVIFNLISS PVSNLAFENV FNILQYNRSN VNAVRGAVRL MRFLMLQEVK NDAIASITLS SSIEFTEFPL GFNENVDFEI LGTVYLFLRT PSILNRLNFL DWHRILNILM YCSQYLPLKA STSKEAFSKT AAFANIYDRV LDFLDFEALI PLLQQFQVKL VFFLKDVLPV LKPKIRKKLL RLFETYNLIF PCNQYWVFNL EFLLGIYQCK TFDLEDRALL FKLVEDACSV ADENSAPILC SKFLFPVIES FSKESDDCVV SPVYNMLFFL SVNFQNPGLK DCIDHIFQQL ISDTSSVTVR RLATSTLIRL FYYYYDLRDA VPIQETLAKM LEILETPSFP FVSRMLCLQF FLRFRANGTS IYICENIDLN EPFKVLNVDS ELIPAVYPIS DSFVNSATVE KHIWERKEND LIKISNHSTE YGKDFVTFPT SSLLRFYRKS MATESNWTIL MFMITHLADQ ISNRSMFIGA LEEIYNLLDF MCDIVFERVS ISAEIPSNIR KANIMIPILQ NVQMLFVYHD QFSRAQEDEL VSVFFAGLQK WNEACHVSIH SLMLCCYELP VSIRKQLPAI LVTLSRLITK PDLSVHILEF LCSLARLPDL IANFTDADYR QIFAIALKYI QHRDFTKESK DSNDTESILK NSYSSYVLAL AYSVLQIWFL SLRLTERKKF VPWILRGLKL ASEGKPLEDL CLVQYDMMQQ FCYSNSDINN QTSTFVDSDV ESETWIRGNS LFTINVSVNS GFLEAVIRRP TGTTQYTFRN EASLQKFLWE ENLTSSKALT RGLLCTPSSF VSHFLDPHGI SLYNQPLLLP SNDDSVRRAI SVFDRIPVIE SLKAGLVYVG YQQRREADIL ANTNPSEDFL TFLNGLGTLF ELKTDQKVFA GGLDRENDID GAFAYCWKDK VTQMVFHCTT MMPTNIEHDP GCTLKKRHIG NDFVTIIFNE SGLEYDFDTI PSQFNFVNIV ITPESESIRR TGRQIKFYKV KALTKYDIDF SLFRRYKIVS SDALPAIVRD VTLNAAVFSH IYHRSAGDYV HIWAERLRQL KRLREKFQAS VLPEDYNLDE QTKTKLQNGT NFSDFTSYL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.

Gene References into Functions

The genome of Schizosaccharomyces pombe contains tsc1(+) and tsc2(+), homologs of human Tsc1 and Tsc2, respectively. Deletion of either tsc1(+) or tsc2(+) affects gene induction upon nitrogen starvation. PMID:16624901
Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe PMID:17556368

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Subcellular Location

Cytoplasm. Nucleus.

Database Links

KEGG: spo:SPAC630.13c

STRING: 4896.SPAC630.13c.1

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