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Recombinant Schizosaccharomyces pombe DNA topoisomerase 2 (top2), partial

Recombinant Schizosaccharomyces pombe DNA topoisomerase 2 (top2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

top2

Uniprot NO.

P08096

Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Source

Yeast

Expression Region

1-1485

Target Protein Sequence

MSIDADFSDY EDEASGDENV LPNTTTKRKA STTSSKSRAK KASTPDLRQT SLTSMTASEQ IPLVTNNGNG NSNVSTQYQR LTPREHVLRR PDTYIGSIEP TTSEMWVFDS EKNKLDYKAV TYVPGLYKIF DEIIVNAADN KVRDPNMNTL KVTLDPEANV ISIYNNGKGI PIEIHDKEKI YIPELIFGNL LTSSNYDDNQ KKVTGGRNGY GAKLCNIFST EFVVETADKE RMKKYKQTWY DNMSRKSEPV ITSLKKPDEY TKITFKPDLA KFGMDKIDDD MVSIIKRRIY DMAGTVRETK VYLNNERISI SGFKKYVEMY LASDTKPDEE PPRVIYEHVN DRWDVAFAVS DGQFKQVSFV NNISTIRGGT HVNYVANKIV DAIDEVVKKE NKKAPVKAFQ IKNYVQVFVN CQIENPSFDS QTKETLTTKV SAFGSQCTLS DKFLKAIKKS SVVEEVLKFA TAKADQQLSK GDGGLRSRIT GLTKLEDANK AGTKESHKCV LILTEGDSAK SLAVSGLSVV GRDYYGVFPL RGKLLNVREA SHSQILNNKE IQAIKKIMGF THKKTYTDVK GLRYGHLMIM TDQDHDGSHI KGLIINYLES SYPSLLQIPG FLIQFITPII KCTRGNQVQA FYTLPEYEYW KEANNNGRGW KIKYYKGLGT SDHDDMKSYF SDLDRHMKYF HAMQEKDAEL IEMAFAKKKA DVRKEWLRTY RPGIYMDYTQ PQIPIDDFIN RELIQFSMAD NIRSIPSVVD GLKPGQRKVV YYCFKRNLVH ETKVSRLAGY VASETAYHHG EVSMEQTIVN LAQNFVGSNN INLLMPNGQF GTRSEGGKNA SASRYLNTAL SPLARVLFNS NDDQLLNYQN DEGQWIEPEY YVPILPMVLV NGAEGIGTGW STFIPNYNPK DITANLRHML NGEPLEIMTP WYRGFRGSIT KVAPDRYKIS GIINQIGENK VEITELPIRF WTQDMKEYLE AGLVGTEKIR KFIVDYESHH GEGNVHFNVT LTEAGMKEAL NESLEVKFKL SRTQATSNMI AFDASGRIKK YDSVEDILTE FYEVRLRTYQ RRKEHMVNEL EKRFDRFSNQ ARFIHMIIEG ELVVSKKKKK DLIVELKEKK FQPISKPKKG HLVDLEVENA LAEEEQSGDV SQDEDSDAYN YLLSMPLWSL TYERYVELLK KKDEVMAELD ALIKKTPKEL WLHDLDAFEH AWNKVMDDIQ REMLEEEQSS RDFVNRTKKK PRGKSTGTRK PRAIAGSSSS TAVKKEASSE SKPSTTNRKQ QTLLEFAASK EPEKSSDINI VKTEDNSHGL SVEENRISKS PGLDSSDSGK SRKRSQSVDS EDAGSKKPVK KIAASASGRG RKTNKPVATT IFSSDDEDDL LPSSLKPSTI TSTKASAKNK GKKASSVKKQ SPEDDDDDFI IPGSSSTPKA SSTNAEPPED SDSPIRKRPT RRAAATVKTP IYVDPSFDSM DEPSMQDDSF IVDNDEDVDD YDESD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Gene References into Functions

Rrp2 possesses SUMO-binding ability and prevents excessive Top2 degradation by competing against the SUMO-targeted ubiquitin ligase (STUbL) for SUMO chain binding and by displacing SUMOylated Top2 from DNA. PMID:28552615
DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe. PMID:21767457
topoisomerase II has a role in disentangling dysfunctional telomeres PMID:19680223

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Subcellular Location

Nucleus.

Protein Families

Type II topoisomerase family

Database Links

KEGG: spo:SPBC1A4.03c

STRING: 4896.SPBC1A4.03c.1

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