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Recombinant Saimiri sciureus Membrane cofactor protein (CD46)

Recombinant Saimiri sciureus Membrane cofactor protein (CD46)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CD46

Uniprot NO.

O62685

Species

Saimiri sciureus (Common squirrel monkey)

Source

Yeast

Expression Region

35-285

Target Protein Sequence

CGPPPT FVAMELTSRP KPYYKVGEQV EYDCKKGYHH FAPFLTHTVC DRNHTWLPIS DAPCVKKVCH YIPNPAHGQA ILANGTYSFG NQLHFICNDG YYLIGKAILY CELKGSDAVW SGRPPICQKI LCKPPPTIKN GKHTFSEVDV FEYLDAVTYS CDPAPGPDPF SLVGESTIYC RDSLGWSGDP PECKVVKCRF PVIENGRQTA GFGIKFYYNA AVMFECYEGF HIIGSDTIVC NSNSTWDPPV PKCVK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein.

Tissue Specificity

Present in blood and sperm. Isoform 2, but not isoform 1, is present at the erythrocyte membrane (at protein level).

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