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Recombinant Saccharomyces cerevisiae Niemann-Pick type C-related protein 1 (NCR1), partial

Recombinant Saccharomyces cerevisiae Niemann-Pick type C-related protein 1 (NCR1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

NCR1

Purity

>85% (SDS-PAGE)

Target Names

NCR1

Uniprot NO.

Q12200

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.

Gene References into Functions

Authors show that yeast cells lacking Ncr1p, an orthologue of mammalian NPC1, exhibited a higher sensitivity to hydrogen peroxide and a shortened chronological lifespan. PMID:24286211
Results identify the first phenotype caused by deletion of NCR1 from the yeast genome, resistance to the ether lipid drug, edelfosine. PMID:16138904

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Subcellular Location

Vacuole membrane; Multi-pass membrane protein.

Protein Families

Patched family

Database Links

KEGG: sce:YPL006W

STRING: 4932.YPL006W

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