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Recombinant Saccharomyces cerevisiae Double-strand break repair protein MRE11 (MRE11), partial

Recombinant Saccharomyces cerevisiae Double-strand break repair protein MRE11 (MRE11), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

MRE11

Uniprot NO.

P32829

Alternative Names

MRE11; YMR224C; YM9959.06C; Double-strand break repair protein MRE11

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Expression Region

1-692

Target Protein Sequence

MDYPDPDTIR ILITTDNHVG YNENDPITGD DSWKTFHEVM MLAKNNNVDM VVQSGDLFHV NKPSKKSLYQ VLKTLRLCCM GDKPCELELL SDPSQVFHYD EFTNVNYEDP NFNISIPVFG ISGNHDDASG DSLLCPMDIL HATGLINHFG KVIESDKIKV VPLLFQKGST KLALYGLAAV RDERLFRTFK DGGVTFEVPT MREGEWFNLM CVHQNHTGHT NTAFLPEQFL PDFLDMVIWG HEHECIPNLV HNPIKNFDVL QPGSSVATSL CEAEAQPKYV FILDIKYGEA PKMTPIPLET IRTFKMKSIS LQDVPHLRPH DKDATSKYLI EQVEEMIRDA NEETKQKLAD DGEGDMVAEL PKPLIRLRVD YSAPSNTQSP IDYQVENPRR FSNRFVGRVA NGNNVVQFYK KRSPVTRSKK SGINGTSISD RDVEKLFSES GGELEVQTLV NDLLNKMQLS LLPEVGLNEA VKKFVDKDEK TALKEFISHE ISNEVGILST NEEFLRTDDA EEMKALIKQV KRANSVRPTP PKENDETNFA FNGNGLDSFR SSNREVRTGS PDITQSHVDN ESRITHISQA ESSKPTSKPK RVRTATKKKI PAFSDSTVIS DAENELGDNN DAQDDVDIDE NDIIMVSTDE EDASYGLLNG RKTKTKTRPA ASTKTASRRG KGRASRTPKT DILGSLLAKK RK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Gene References into Functions

error-prone BIRs are increased in homeologous recombination in wild-type and in mre11A470T cells. PMID:29705126
Resection of DNA breaks is impaired when either Sae2 activity is blocked, suggesting roles for both Mre11 and Sae2 nuclease activities in promoting the processing of DNA ends in vivo. PMID:28970327
A major DSB sensor, the Mre11-Rad50-Xrs2 (MRX) complex, is regulated by cell cycle-dependent phosphorylation specifically in mitosis. PMID:24553123
propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection PMID:21876003
results identify a function for MRE11 in the response to topoisomerase poisons that is distinct from its functions in DSB repair or meiotic DNA processing PMID:21060845
Mre11 mutation promotes telomere recombination and an efficient bypass of senescence. PMID:20421597
Mre11 nuclease activity is essential for resection in the absence of extensive double-strand break end resection enzymes. PMID:20834227
Mre11 mutations are associated with increased rates of spontaneous loss of heterozygosity leading to genome instability. PMID:20410660
The nuclease function of Mre11 is required for RMX-mediated recombinational repair and telomere stabilization in mitotic cells. PMID:15126391
Mre11 nuclease is not involved in the extensive 5' to 3' resection of double-strand breaks PMID:15485933
Rad50 hook is critical for Mre11 complex-dependent DNA repair, telomere maintenance and meiotic double-strand break formation PMID:15852023
Srs2 and Sgs1 associate with Mre11 in different subcomplexes following checkpoint abd CDK1-mediated Srs2 phosphorylation. PMID:15964827
These data suggest that Mre 11p can act as a positive and negative regulator of TRD in context of the MRX complex that is essential for TRD. PMID:15990364
S.cerevisiae Mre11 protein possesses high binding affinity for G4 DNA and cleaves G-rich sequences. PMID:16116037
Mutations in Mre11 phosphoesterase motif I impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. PMID:16143598
Mre11/Rad50 complexes from three organisms catalyze the reversible adenylate kinase reaction in vitro. PMID:17349953
Mre11 is involved in the regulation of a specific class of genes during spore development through its C-terminus domain. PMID:17396017
Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing. PMID:18335232