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Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH3 (MLH3), partial

Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH3 (MLH3), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

MLH3

Purity

>85% (SDS-PAGE)

Target Names

MLH3

Uniprot NO.

Q12083

Alternative Names

MLH3; YPL164C; P2550; DNA mismatch repair protein MLH3; MutL protein homolog 3

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Expression Region

1-715

Target Protein Sequence

MSQHIRKLDS DVSERLKSQA CTVSLASAVR EIVQNSVDAH ATTIDVMIDL PNLSFAVYDD GIGLTRSDLN ILATQNYTSK IRKMNDLVTM KTYGYRGDAL YSISNVSNLF VCSKKKDYNS AWMRKFPSKS VMLSENTILP IDPFWKICPW SRTKSGTVVI VEDMLYNLPV RRRILKEEPP FKTFNTIKAD MLQILVMHPM ISLNVQYTDK LRINTEVLFR SKNITEGLTK HQQMSQVLRN VFGAIIPPDM LKKVSLKFNE YQIEGIISKM PVGLKDLQFI YINGRRYADS AFQGYVDSLF QAQDFGEKGM SLLKTKSVGK PYRSHPVFIL DVRCPQTIDD LLQDPAKKIV KPSHIRTIEP LIVKTIRSFL TFQGYLTPDK SDSSFEIVNC SQKTATLPDS RIQISKRNQV LNSKMKIARI NSYIGKPAVN GCRINNSTIN YEKIKNIRID GQKSRLRNKL SSRPYDSGFT EDYDSIGKTI TDFSISRSVL AKYEVINQVD KKFILIRCLD QSIHNCPLLV LVDQHACDER IRLEELFYSL LTEVVTGTFV ARDLKDCCIE VDRTEADLFK HYQSEFKKWG IGYETIEGTM ETSLLEIKTL PEMLTSKYNG DKDYLKMVLL QHAHDLKDFK KLPMDLSHFE NYTSVDKLYW WKYSSCVPTV FHEILNSKAC RSAVMFGDEL TRQECIILIS KLSRCHNPFE CAHGRPSMVP IAELK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.

Gene References into Functions

mlh3Delta showed approximately 30% genome-wide reduction in crossovers and loss of the obligate crossover, but nonexchange chromosomes were efficiently segregated. PMID:28315832
Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast. PMID:23316435
Overexpression of the mlh3-D523N mutant allele conferred a dominant-negative phenotype with respect to mismatch repair. PMID:18505871

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Subcellular Location

Nucleus.

Protein Families

DNA mismatch repair MutL/HexB family

Database Links

KEGG: sce:YPL164C

STRING: 4932.YPL164C

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