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Recombinant Rat cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a)

Recombinant Rat cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Prkar1a

Uniprot NO.

P09456

Alternative Names

Prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit; N-terminally processed]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-381

Target Protein Sequence

MASGSMAASE EERSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EARQIQSLQK SGIRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFPVSFIA GETVIQQGDE GDNFYVIDQG EMDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGTA AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Gene References into Functions

role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus PMID:25587115
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis. PMID:24307699
a key role for AKAP-targeted PKA in control of heart rate and contractile function PMID:20581396
cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes PMID:11818504
oocytes express AKAP140 that is phosphorylated during meiosis. AKAP140 and its phosphorylation state may influence the translocation of the R subunits of PKA throughout resumption of meiosis. PMID:12088872
GABA B receptor-mediated inhibitory action on GABA release was mediated via decreases in protein kinase A activity. PMID:12815184
protein kinase A is controlled by Fos-related antigen 2 and has a role in inducing CCAAT/enhancer-binding protein beta expression in osteoblasts PMID:15299028
the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding PMID:16109722
dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling PMID:17610895