Recombinant Rat Yorkie homolog (Yap1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Yap1

Purity

>85% (SDS-PAGE)

Target Names

Yap1

Uniprot NO.

Q2EJA0

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-469

Target Protein Sequence

MEPAQQPPPQ PAPQGPAPPS VSPAGTPAAP PAPPAGHQVV HVRGDSETDL EALFNAVMNP KTANVPQTVP MRLRKLPDSF FKPPEPKSHS RQASTDAGTA GALTPQHVRA HSSPASLQLG AGTLTASGVV SGPAATPAAQ HLRQSSFEIP DDVPLPAGWE MAKTSSGQRY FLNHNDQTTT WQDPRKAMLS QLNVPTSASP AVPQTLMNSA SGPLPDGWEQ AMTQDGEVYY INHKNKTTSW LDPRLDPRFA MNQRITQSAP VKQPPPLAPQ SPQGGVLGGG SSNQQQQIQL QQLQMEKERL RLKQQELFRQ ELALRSQLPS LEQDGGTQNA VSSPGMTQEL RTMTTNSSDP FLNSGTYHSR DESTDSGLSM SSYSIPRTPD DFLNSVDEMD TGDTISQSTL PSQQSRFPDY LEALPGTNVD LGTLEGDAMN IEGEELMPSL QEALSSEILD VESVLAATKL DKESFLTWL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation.; Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.; Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.; Attenuates p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.

Gene References into Functions

Here we propose that FGF promotes Hippo/YAP-signaling during lens cell proliferation and differentiation, with FGF-induced nuclear-YAP expression playing an essential role in promoting the proliferation of lens epithelial cells. PMID:29355736
results suggest that the Hippo-YAP/TAZ signaling pathway participates in periodontal tissue remodeling through various mechanisms PMID:29356923
YAP1 is protective against VSMC apoptosis induced by ER stress PMID:28951205
Cell proliferation assay indicated a significant decrease in cell proliferation after Yes-associated protein (YAP) shRNA treatment. PMID:28915934
YAP modulates cAMP signaling in Sertoli cell which may be critical for testicular function. PMID:28428044
Our findings identify YAP as a required signaling factor through which fibrous substrate topography influences cell behavior and highlights topography as a key design parameter for engineered biomaterials. PMID:27889666
Cyclic tensile strain can modulate YAP and ERK activation, which may subsequently regulate cell cycle progression in growth plate chondrocytes. PMID:26694636
Mechanisms that underlie neuropathic pain remain elusive. We have demonstrated recently that nerve injury can activate Wnt signaling, which becomes a trigger for the development of neuropathic pain. We report that transcriptional regulators YAP and TAZ, which orchestrate Wnt response via incorporation in the beta-catenin destruction complex, are key in the pathogenesis of neuropathic pain and may serve as an "ON-OFF" s... PMID:27683908
Up-regulation of Yap1 is associated with furan hepatotoxicity. PMID:27371368
This study identified YAP1 as enhancers of neurite outgrowth. PMID:26306672
YAP is involved via the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury. PMID:26574480
YAP increases the abundance of miR-206, which in turn plays an essential role in mediating hypertrophy and survival by silencing Forkhead box protein P1 in cardiomyocytes. PMID:26333362
YAP activates the phosphoinositol-3-kinase-AKT pathway and regulates cardiomyocyte proliferation and survival. PMID:25249570
Report dynamic changes in the Hippo signaling pathway and YAP activation during liver regeneration, which stabilize when the liver-to-body weight ratio reaches homeostatic levels. PMID:24875096
YAP inactivation is conducive to the maintenance of the chondrogenic cartilage phenotype. PMID:23543231
Mesenchymal stem cell and chondrocyte fates in response to mechanical cues are regulated by Yes-associated protein. PMID:23442010
YAP plays a novel integrative role in smooth muscle (SM) phenotypic modulation by inhibiting SM-specific gene expression while promoting SM proliferation and migration in vitro and in vivo. PMID:22922963
studies demonstrate that Yap1 is a crucial regulator of cardiomyocyte proliferation, cardiac morphogenesis, and myocardial trabeculation PMID:22308401