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Recombinant Rat Von Hippel-Lindau disease tumor suppressor (Vhl)

Recombinant Rat Von Hippel-Lindau disease tumor suppressor (Vhl)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Vhl

Purity

>85% (SDS-PAGE)

Target Names

Vhl

Uniprot NO.

Q64259

Alternative Names

Vhl; von Hippel-Lindau disease tumor suppressor; pVHL

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-185

Target Protein Sequence

MPRKAASPEE AERMPGSEEI EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP VYTLKERCLQ VVRSLVKPEN YRRLDIVRSL YEDLEDHPNV RKDIQRLTQE HLENQALGEE PEGVH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

Gene References into Functions

VHL functions to induce neuronal differentiation of neural stem/progenitor cells and skin-derived precursors. PMID:29401731
that the change of VHL protein expression was related to neuronal apoptosis after spinal cord injury PMID:27324785
we observed that microtubule network stabilization downregulated Ran-mediated pVHL nuclear accumulation, which in turn led to the upregulation of HIF-1alpha protein PMID:25779090
The protein levels of HIF-1alpha were down-regulated through overexpression of pVHL and were up-regulated through knockdown of pVHL in hypoxic cardiomyocytes. PMID:22506063
VHL peptide-delivered MSCs differentiated into neuron-like cells, and that engrafted VHL peptide-delivered marrow stromal cells (MSCs) more recovered the behaviors of the rats than that of nondelivered MSCs. PMID:20125055
Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells. PMID:11912140
pVHL specifically binds the hyperphosphorylated Rpb1 in a proline-hydroxylation-dependent manner, targeting it for ubiquitination PMID:12604794
Tyrosine hydroxylase promoter activity is regulated by the von Hippel-Lindau tumor suppressor protein and HIF1alpha and HIF2alpha in PC12 cells PMID:12675925
Significantly greater axonal outgrowth was observed for the Von Hippel-Lindau protein-transfected cells treated with the inhibitor Lavendustin A than for those not so treated. PMID:15094462
Hypoxia induction or normoxic acidosis can neutralize the function of VHL by triggering its nucleolar sequestration, a regulatory mechanism of protein function that is observed rarely. PMID:15181450
Von Hippel-Lindau protein (VHL) pre-induction by thrombin aggravates glomerulonephritis (GN), and the increase in VHL expression due to Habu snake venom might be involved in accelerating onset of GN. PMID:17519558