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Recombinant Rat Voltage-dependent anion-selective channel protein 2 (Vdac2), partial

Recombinant Rat Voltage-dependent anion-selective channel protein 2 (Vdac2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Vdac2

Uniprot NO.

P81155

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.

Gene References into Functions

the coupling of VDAC2 with RyR2 is essential for Ca2+ transfer from the sarcoplasmic reticulum to mitochondria in the heart. PMID:22867515
Multiple spots on 2D gel representing VDAC2 protein forms with different isoelectric points. PMID:19688190
Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. PMID:18802025

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Subcellular Location

Mitochondrion outer membrane. Membrane.

Protein Families

Eukaryotic mitochondrial porin family

Tissue Specificity

Highly expressed in heart, kidney, brain and ascitic tumor with very low levels in liver. Expressed in the head region of epididymal sperm.

Database Links

UNIGENE: Rn.162037

KEGG: rno:83531

STRING: 10116.ENSRNOP00000018462

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