Home
Product
Protein
Recombinant Proteins
Recombinant Rat Vesicle-associated membrane protein 8 (Vamp8), partial

Recombinant Rat Vesicle-associated membrane protein 8 (Vamp8), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Vamp8

Purity

>85% (SDS-PAGE)

Target Names

Vamp8

Uniprot NO.

Q9WUF4

Alternative Names

Vamp8Vesicle-associated membrane protein 8; VAMP-8; Endobrevin; EDB

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.

Gene References into Functions

acute inhibition of VAMP8-mediated secretion during pancreatitis triggers intracellular trypsin accumulation and loss of the early endosomal compartment PMID:28242757
The authors took a proteomics approach using a PKCB knockout mast cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at multiple residues in the SNARE domain. PMID:27402227
Individual pancreatic acinar cells express VAMP 8-specific populations of zymogen granules that orchestrate the constitutive and calcium(2+)-regulated secretory pathways. PMID:17272274
VAMP8, which also mediates fusion of late endosomes and lysosomes, plays a major role in hexosaminidase release PMID:17618625

Hide All

Subcellular Location

Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Midbody. Cell membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein.

Protein Families

Synaptobrevin family

Tissue Specificity

Expressed (at protein level) at a high level in kidney, lung and spleen; at a lower level in testis, liver, brain and heart. Expressed in kidney and retinal pigment epithelium derived cell line.

Database Links

UNIGENE: Rn.82672

KEGG: rno:83730

STRING: 10116.ENSRNOP00000017301

Promotions