Recombinant Rat Usherin (Ush2a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ush2a

Purity

>85% (SDS-PAGE)

Target Names

Ush2a

Uniprot NO.

Q8K3K1

Alternative Names

Ush2a; Usherin; Usher syndrome type IIa protein homolog; Usher syndrome type-2A protein homolog

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

34-1512

Target Protein Sequence

VFPRLEN VGAFKKVSIV PSHATCGYPG PSTFCRSAVA AEHAQLCAER LCIQDCPYRS ASPPYTALLE GLRSCIPADH GDLHPYSRSN STSFIFGSHK NCPSLQAPRL AAEFTLAVWL KPERGSTMCV LEKTADGQIV FKVTISERET MFYYRTVNGL QPPIKVMTPG RILMKKWIHH TVQVHETEVS SFVDGLEENS TAFDTRTLRD SIMDSVPSTV LIGQSLNGSE LFVGRMQDFR LYNVSLTNRE ILELFSGDLP HLHIQSHCRC PGSHPRVHPS VQQYCIPNGV EDTLQHRVSR LNPEAHPLSF INDDDVATSW ISHVFTDITQ LNQGVAISID LENGQYQVFQ ITIRFSSPQP VAMRIQRKKA DKSLWEDWQY FARNCSVWGM KNNGDLENPN SVNCLQFPEF IPFSHGNVTF DLLTSGQKHR PGDYDFYNSS LLQEFMTATQ IRLYFRGLFY PAWHTVDSRH RYYAVDEITI IGRCQCHGHA ETCDRTRRPY RCLCSPHSFT EGPQCGRCSP LYNDKPFRSG NKVHAFNCKP CQCHGHASSC HYDASMDPFP LEYNRGGGGV CDDCQHHTTG RNCESCQDYF YRPIGADPAD PEVCKHCDCN RDGTRNGSLL CDLVGDQCDC KRRVSGRRCF RCHIGFYGLQ ALDPDCCRPC DCNPSGTVDG DITCHHNSGQ CSCKANVIGL RCDRCSFGFK FLRSLNADGC EPCHCNLHGS VNQLCDPLSG QCVCKKEAKG LRCDVCRENF YGLPWSACEV CDCNRAGTQA GTVCDAETGQ CVCKPSVGGR RCSECKEGYF NLRQNDSHLC LPCNCEKTGT VNGSLLCDKS TGQCPCKLGV TGLRCHQCKP HRFNLTMDNP QGCQACDCDS LGTLLGSMCD PVSGQCLCLP HRQERRCVQC QPGCYSSPSN ATGCLPCLCH TVATKNCICN SVTGHCYCPD PSTTGLSWHQ CQDRYFRFDP LTGRCRPCHC HVAGASNGTC DAVTGQCFCK EFVTGSKCDT CVPGASHLDV NNLLACSKTP SQQPPPRGRV QSSSAINLSW SPPDFPNAHW LTYTLFRDDS EIYTTDDQHP YYTQYFLDTS LSPHTAYSYY IETSNVHSST RSIPVIYKTK PEGSEGHLNL THIIPVASDS ITLVWTGLSN HSGPIEKYVL SCTPVDHTEP CVSYEGPETS ATIRNLVPFT QYCFSVQGCT NGSCLYSSPI TVTTAQAPPQ RQEPPTVWKI SPTELKVEWS RPVDSNGVII RYELYMKRWP STEESLVFES HGWFHSHPAS PSANQSENVL QDPQVSTVLS GLDPHTEYAF RVLAVNMAGS VSSAWASERT GESAPVFMAA PSVSPLSPYS LSVSWEKPAE NFTRGEIIGY KISMVSERSP QRDVPVMCSK LVHFAESQDQ SYIVQRLKPY RTYSFTVSLC ASVGCVTSAL GEGQTLTAGK NVLTNTKKCT HVGNQYYRSA VLWASYMSSL FTAPSSDILD VVYLESFKQN QH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.

Subcellular Location

[Isoform 2]: Secreted.; Cell projection, stereocilium membrane. Photoreceptor inner segment.

Tissue Specificity

Present in the synaptic terminals of inner ear hair cells (at protein level). Predominantly expressed in the retina and cochlea. Weakly expressed in brain and kidney. Detectable from E17 in the neural epithelium, but not in the retinal pigment epithelium

Database Links

UNIGENE: Rn.200477

STRING: 10116.ENSRNOP00000004992

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