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Recombinant Rat Ubiquitin-like protein ATG12 (Atg12)

Recombinant Rat Ubiquitin-like protein ATG12 (Atg12)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Atg12

Purity

>85% (SDS-PAGE)

Target Names

Atg12

Uniprot NO.

Q2TBJ5

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-141

Target Protein Sequence

MAEDPEAVLQ LPAAPAAAAG ESLLELSPET AIPEPPSSVA VSPGTEEPPG DTKKKIDILL KAVGDTPIMK TKKWAVERTR TVQALIDFIR KFLRLLASEQ LFIYVNQSFA PSPDQEVGTL YECFGSDGKL VLHYCKSQAW G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Gene References into Functions

Study demonstrated that miR-23b expression was significantly downregulated following traumatic brain injury (TBI). In model TBI, overexpression of miR-23b reduced the lesion volume, brain edema and neuronal apoptosis, and improves cognitive dysfunction. miR-23b specifically bound with the 3' UTR of ATG12 mRNA and modulated its translation; suppressed neuronal autophagy by directly targeting ATG12 expression. PMID:27630106

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Subcellular Location

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.

Protein Families

ATG12 family

Database Links

UNIGENE: Rn.6224

KEGG: rno:361321

STRING: 10116.ENSRNOP00000000170

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