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Recombinant Rat Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)

Recombinant Rat Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ptpn6

Uniprot NO.

P81718

Alternative Names

Ptpn6; Ptph6; Tyrosine-protein phosphatase non-receptor type 6; EC 3.1.3.48; Protein-tyrosine phosphatase SHP-1

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-613

Target Protein Sequence

MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ VTHIRIQNSG DFYDLYGGEK FATSTELVEY YTQQQGILQD RDGTIIHLKY PLNCSDPTSE RWYHGHMSGG QAESLLQAKG EPWTFLVRES LSQPGDFVLS VLNDQPKAAP GSPLRVTHIK VMCEGGRYTV GGSETFDSLT DLVEHFKKTG IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED TAKAGFWEEF ESLQKQEAKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV MTTREVEKGR NKCVPYWPEV GTQRVYGLYS VTNCKEHDTA EYKLRTLQIS PLDNGDLVRE IWHYQYLSWP DHGVPSEPGG VLSFLDQINQ RQESLPHAGP IIVHCSAGIG RTGTIIVIDM LMESVSTKGL DCDIDIQKTI QMVRAQRSGM VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QRGQESEYGN ITYPPALRSA HAKASRTSSK HKEEVYENVH SKNKKEEKVK KQRSADKEKN KGSLKRNISL TPCRGLRWAD RDL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Gene References into Functions

Shp-1 increased in DRGs of rats with CFA-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia. PMID:25790452
Andrographolide activates the PP2A-p38MAPK-p53-Bax cascade. PMID:25007834
SHP-1 as an off-switch of PDGFR signaling appears to emerge as a valuable molecular target to trigger as to prevent hepatic stellate cells (HSC) proliferation and the fibrogenic effects of HSC activation. PMID:24140598
Postnatal day-15 hindbrain contains a complex of proteins recruited by angiotensin (Ang)-II SHP-1 protein tyrosine activation, which participates in an active signal transduction mechanism. PMID:22120166
The activity of SHP-1 was decreased after high partial pressure of oxygen treatment no matter what the duration was, while the activity of CD45 was decreased only after high partial pressure of oxygen that led to inhibition of lymphocyte function. PMID:21166153
Adaptor protein 3BP2 directly interacts with Tyr564-phosphorylated form of SHP-1 and positively regulates the function of SHP-1 in FcepsilonRI-mediated signaling in mast cells. PMID:22077594
Nicotine-induced tyrosine phosphorylation of JAK2 and neuroprotection against Abeta (1-42) in PC12 cells are blocked by Ang II via AT2 receptor-induced activation of SHP-1 PMID:14657181
Src homology protein tyrosine phosphatase-1 might play a critical role in the transcriptional regulation of MCP-1 expression PMID:14684844
SHP-1 may play a role in limiting CNS inflammation following injury such as deafferenting the auditory brainstem. PMID:15341919
SHP-1 has a role in myocardial infarction in rats PMID:16223786
SHP-1 phosphatase activation, by Angiotensin II (Ang II) AT(2) receptors Involvement of c-Src tyrosine kinase PMID:18680145