Recombinant Rat Tuberin (Tsc2), partial

1. TFE3 activation by mTORC1 signaling is involved in the development of abnormal ductal structures in Tsc2 knockout teratomas. PMID:26352760
2. Formation of ROS and activity of NADPH oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells. PMID:27278252
3. Heterozygous TSC2 mutation not only affects the liver metabolism, but also skeletal muscle metabolism, via mitochondrial dysfunction. PMID:27031579
4. Therefore, we conclude that glycolysis is restrained in the livers of TSC2 heterozygous mutant rats, and these defects lead to abnormal production of acetoacetate. PMID:26550928
5. In vitro differentiation experiments using these ESCs combined with in vivo experiments may reveal the mechanism of the tissuespecific pathogenesis caused by the Tsc2 mutation and identify specific new therapeutic targets. PMID:25738543
6. The N525S Tsc2 variant causes dominant embryonic lethality in Eker rats. PMID:25088526
7. In conclusion, dendritic spine abnormalities in TSC neurons may be caused through activation of Rheb, but not through of mTORC1. PMID:24889507
8. these results demonstrate that TSC2-deficient cells have enhanced choline phospholipid metabolism and reveal a novel function of the TSC proteins in choline lysoglycerophospholipid metabolism PMID:25780943
9. oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2 PMID:24444419
10. Kidney mass was significantly greater in partially tuberin-deficient (TSC2(+/-) ) diabetic rats than wild-type diabetic rats. TSC2(+/-) rats exhibited significant increases in the levels of phospho-tuberin and fibronectin expression in the kidney cortex. PMID:22904348
11. Our study shows that Tsc2 haploinsufficiency and developmental status epilepticus in wild-type and Tsc2 (+/-) rats independently lead to autistic-like social deficit behaviors. PMID:20927644
12. Data demonstrate that mTORC2-dependent activation of RhoA is required for TSC2-null cell growth and survival. PMID:21482669
13. the tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes, mediated in part by cleavage of PARP by YY1. PMID:21289215
14. Results describe the expression of Nth1 and Tsc2 genes during disease progression in hepatitis/liver tumorigenesis the Long-Evans Cinnamon rat. PMID:20033472
15. TSC2 has a role in controlling cell polarity and migration by regulating CDC42 and RAC1 activation PMID:20530489
16. Aberrant expression of HMGA2 in uterine leiomyoma is associated with loss of TSC2 tumor suppressor gene function. PMID:12097287
17. Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. PMID:12110509
18. The complex of this protein with hamartin negatively regulates beta-catenin signaling activity. PMID:12511557
19. Polycystic kidney results from a loss of the tuberous sclerosis 2 tumor suppressor gene during development. PMID:12547704
20. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma is associated with loss of Tsc-2 tumor suppressor gene. PMID:12750296
21. the TSC1.TSC2 complex is regulated by pam and its ortholog highwire PMID:14559897
22. In Eker rats, many if not all cytomegalic neurons of a cortical tuber occur in the absence of allelic loss. PMID:14566415
23. restoration of tuberin expression in QT-RRE cells by transient transfection with Tsc-2 cDNA substantially decreased both ERK and B-Raf activity, with only modest changes in Raf-1 activity PMID:14612383
24. Tsc2 is a component of membrane microdomains and mediates caveolin-1 localization in post-Golgi transport. PMID:15093748
25. Mutant rats are models for hereditary renal caricnoma (review) PMID:15579027
26. The TSC2 modulates actin dynamics and cell adhesion and the TSC1-binding domain (TSC2-HBD) is essential for this function of TSC2. PMID:15611338
27. TSC2+/- rats, which are virtually free of cerebral hamartomas, exhibit enhanced episodic-like memory and enhanced responses to chemically-induced kindling. PMID:16300636
28. Increased lymphangioleiomyomatosis (LAM) cell growth is associated with constitutive S6K1 activation, which is extinguishable by TSC2 expression. PMID:16424383
29. REDD1 functions upstream of Tuberin and Rheb to down-regulate mTOR signaling in response to dexamethasone PMID:17074751
30. study presents the cytoplasmic/nuclear distribution of tuberin in cell lines PMID:17458623
31. in granulosa cells, FSH uses a protein kinase A-/ERK-dependent pathway to stimulate TSC2 phosphorylation and mTOR signaling PMID:17510244
32. IFNbeta augments TSC2-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. PMID:18094073
33. These results demonstrate that OGG1 localizes with tuberin preferentially in kidney cortex. Loss of tuberin is accompanied by the loss of OGG1 contributing to tumorigenesis. PMID:18218111
34. there is a dissociation of TSC2 and mTOR phosphorylation in vivo. PMID:18670866
35. G1556S-type mutation-transgenic (GSM-Tg) rats exhibited suppression of macroscopic renal tumors following N-ethyl-N-nitrosourea treatment PMID:18695678
36. findings show that endoplasmic reticulum (ER) stress regulates TSC1/TSC2 complex to limit mTOR activity PMID:19420259

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UNIGENE: Rn.5875

KEGG: rno:24855

STRING: 10116.ENSRNOP00000016221